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ERASE-Seq: A Novel NGS statistical approach

Nov 21, 2017

Liquid biopsy assays have shown great promise as a precision medicine approach to therapy selection and patient monitoring, but significant sensitivity and specificity improvements are still needed. To address this we introduce ERASE-Seq (Elimination of recurrent artifacts and stochastic errors), a method for accurate and sensitive detection of ultra-low frequency DNA variants.
ERASE-Seq differs from previous methods by creating a variant event matrix that includes multiple sample runs and control data. A robust statistical framework is applied at each position in the sequence, providing a 10 to 100-fold reduction in false positive rates compared to published molecular barcoding methods.

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Related technologies: CTC´s and rare cells analysis

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Fluxion Biosciences

With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.

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The Spotlight 59 Oncology Panel is a turnkey solution for Illumina sequencers, offering ultra-sensitive variant detection from low input quantities of DNA.

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