Accelerate to discover

Back to filter

Related topics

Squaraine fluorophore as a NIR-fluorescent probe for the in vivo detection of diagnostic enzymes

Spectral Instruments Imaging

Nov 19, 2018

An oligo(ethylene glycol)-functionalized squaraine fluorophore has been developed as an NIR-fluorescent probe that can...

IncuCyte neuronal activity assay

Sartorius

Nov 13, 2018

The generation and maturation of neuronal networks are necessary characteristics of neurogenesis, providing...

The most advanced software for preclinical imaging research

Bruker Biospin

Nov 7, 2018

Modern imaging laboratories hosting PET/MR instruments profit from the fully integrated common imaging platform...

IZON qEV - Isolate your exosomes in just 15 minutes

IZON

Oct 25, 2018

Extracellular  vesicles  (EVs)  are  prevalent  in biological  fluids  and  are  of  great  interest  to researchers ...

Nov 19, 2018

COY - personalized hypoxic chambers

COY laboratory products

Oct 18, 2018

When your research requires consistent atmospheric control to maintain hypoxia, normoxia, or hyperoxia, you can count...

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs

Fluxion Biosciences

Oct 12, 2018

Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition,...

Target large genomic regions with 10x genomics + SageHLS

Sage Science

Oct 9, 2018

With customized Cas9 nucleases, scientists can now isolate specific large genomic DNA fragments with the SageHLS...

Nov 19, 2018

Coy anaerobic chambers #1 choice in microbiology

COY laboratory products

Oct 5, 2018

Used for over 40 years in anaerobic microbiology research, COY chambers are also critical to many other research areas...

Show all topics (10)

Exploration of melanoma metastases in mice brains using endogenous contrast photoacoustic imaging

Feb 2, 2018

B16F10 murine skin melanoma cells were implanted orthotopically into the mouse brain.
Imaging of melanoma cells in tissue mimicking phantoms showed a linear correlation between PA signal and cell concentration, with a detection limit of 625 cells.
3D ultrasound and spectroscopic PA imaging were performed, looking at melanin, oxy and deoxy-hemoglobin.
Both total hemoglobin content (HbT) and Oxygen saturation (SO2) were assessed.
Higher HbT values were observed in tumors compared to heathy brain of the same volume, whereas SO2 values were much lower in the tumors.
A clear presence of melanin was detected, with 3 times higher PA signal compared to surround brain tissue.
Further regional analysis showed much higher HbT and SO2 signals at the tumor periphery that decrease when moving towards the core.

Photoacoustic (PA) imaging combines the advantages of high optical contrast and high ultrasound resolution at depth, to allow for non-invasive evaluations of endogenous contrasts. This enables non-invasive, contrast agent-free characterization of tumor vasculature and hypoxia, providing new opportunities for understanding cancer progression and treatment response.

Read more

 

Scientific paper
Application

Related technologies: High frequency ultrasound imaging

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 737 202 127

Send Message

Brand profile

VisualSonics FujiFilm

FujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research.

Related products

A new and innovative platform combining ultra high-frequency ultrasound imaging, quantification and education

show detail

Vevo LAZR-X combines high frequency ultrasound and photoacoustics into one platform for high resolution anatomical, functional and molecular imaging

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey