Accelerate to discover

Back to filter

Related topics

Why ventilator so important in the battle against COVID-19?

RWD

Sep 21, 2020

The COVID-19 has caused shortages of medical devices in many countries, especially ventilators. Many companies around...

Imaging Performance of a multimodal module to enhance preclinical irradiator capabilities

Precision X-Ray

Sep 15, 2020

Upgrading an existing irradiator with such a multi-modal imaging device is a reasonable investment in laboratories...

Are you still using traditional methodologies for your Oncology cell metabolism studies?

Sartorius

Sep 10, 2020

In this infographic, learn about the challenges experienced by scientists in analysing cellular metabolism and how...

Using DNA repair and machine learning to improve cancer risk prediction

Luminex

Sep 7, 2020

Across the world, breast cancer continues to be the leading type of cancer in women, accounting for 25% of all cases....

Sep 22, 2020

Quantitative evaluation of pulmonary function with hyperpolarized xenon gas MR

Bruker Biospin

Aug 20, 2020

Hyperpolarized 129Xe MR has been proven to be a powerful tool to evaluate the pulmonary function and has been widely...

Applications of Hyperpolarized 129Xe MRI for functional imaging of the lungs

Bruker Biospin

Aug 11, 2020

2015 marked the first ever translation of hyperpolarized gas MRI to diagnostic clinical practice. Research at the...

Detection of Rare Cells and Circulating Tumor Cells using NovoCyte flow cytometer

Acea Biosciences

Aug 11, 2020

Circulating tumor cells (CTC) are rare cells shed from a solid tumor or metastases that circulate through the...

Sep 22, 2020

Introducing Amnis AI Image Analysis software

Luminex

Aug 4, 2020

Amnis AI Image Analysis Software combines the power of high dimensional data reduction with artificial intelligence,...

Show all topics (10)

Exploration of melanoma metastases in mice brains using endogenous contrast photoacoustic imaging

Feb 2, 2018

B16F10 murine skin melanoma cells were implanted orthotopically into the mouse brain.
Imaging of melanoma cells in tissue mimicking phantoms showed a linear correlation between PA signal and cell concentration, with a detection limit of 625 cells.
3D ultrasound and spectroscopic PA imaging were performed, looking at melanin, oxy and deoxy-hemoglobin.
Both total hemoglobin content (HbT) and Oxygen saturation (SO2) were assessed.
Higher HbT values were observed in tumors compared to heathy brain of the same volume, whereas SO2 values were much lower in the tumors.
A clear presence of melanin was detected, with 3 times higher PA signal compared to surround brain tissue.
Further regional analysis showed much higher HbT and SO2 signals at the tumor periphery that decrease when moving towards the core.

Photoacoustic (PA) imaging combines the advantages of high optical contrast and high ultrasound resolution at depth, to allow for non-invasive evaluations of endogenous contrasts. This enables non-invasive, contrast agent-free characterization of tumor vasculature and hypoxia, providing new opportunities for understanding cancer progression and treatment response.

Read more

 

Scientific paper
Application

Related technologies: High frequency ultrasound imaging

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 255 700 886

Send Message

Brand profile

VisualSonics FujiFilm

FujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research.

Related products

A new and innovative platform combining ultra high-frequency ultrasound imaging, quantification and education

show detail

Vevo LAZR-X combines high frequency ultrasound and photoacoustics into one platform for high resolution anatomical, functional and molecular imaging

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey