Accelerate to discover

Back to filter

Related topics

New technologies to uncover the molecular basis of disorders of sex development

BioNano Genomics

Aug 16, 2018

Newer approaches, such as whole-genome sequencing and whole-genome mapping have the potential to identify novel...

Functional Imaging

Bruker Biospin

Aug 9, 2018

We bring you the latest KOL interview on the Albira Si PET/SPECT/CT from Prof. John Prior, CHUV Lausanne. He describes...

Differentation displacement in acute myeloid leukemia through enhancer activation

Acea Biosciences

Aug 7, 2018

Blast cell differentation is inhibitited by pharmacological targeting of lysine specific demethylase 1 (LSD1). In this...

Great ape genomes laid bare

BioNano Genomics

Aug 3, 2018

Scientists have long been interested in the functional genetic differences that distinguish humans from other ape...

Aug 18, 2018

Dynamic PET imaging and special focus in cardiac kinetic analysis

Bruker Biospin

Aug 1, 2018

Micro-computed tomography, or micro-CT, is being employed by a rapidly increasing number of laboratories for bone...

Novel insights on the mechanical properties of IFs using LUMICKS’ technology

LUMICKS

Jul 30, 2018

The journal Science Advances has recently published the paper ‘Viscoelastic properties of vimentin originate from...

IncuCyte S3 Cell-by-Cell analysis software

Sartorius

Jul 27, 2018

The IncuCyte S3 Live-Cell Analysis System, "Cell-by-Cell Analysis" software module, and IncuCyte reagents provide a...

Aug 18, 2018

xCELLigence AccuWound 96 - Is your Wound Healing assay due for an upgrade?

Acea Biosciences

Jul 26, 2018

Cell migration and invasion are critical to many biological fields. Scratch assay with AccuWound 96 brings...

Show all topics (10)

Exploration of melanoma metastases in mice brains using endogenous contrast photoacoustic imaging

Feb 2, 2018

B16F10 murine skin melanoma cells were implanted orthotopically into the mouse brain.
Imaging of melanoma cells in tissue mimicking phantoms showed a linear correlation between PA signal and cell concentration, with a detection limit of 625 cells.
3D ultrasound and spectroscopic PA imaging were performed, looking at melanin, oxy and deoxy-hemoglobin.
Both total hemoglobin content (HbT) and Oxygen saturation (SO2) were assessed.
Higher HbT values were observed in tumors compared to heathy brain of the same volume, whereas SO2 values were much lower in the tumors.
A clear presence of melanin was detected, with 3 times higher PA signal compared to surround brain tissue.
Further regional analysis showed much higher HbT and SO2 signals at the tumor periphery that decrease when moving towards the core.

Photoacoustic (PA) imaging combines the advantages of high optical contrast and high ultrasound resolution at depth, to allow for non-invasive evaluations of endogenous contrasts. This enables non-invasive, contrast agent-free characterization of tumor vasculature and hypoxia, providing new opportunities for understanding cancer progression and treatment response.

Read more

 

Scientific paper
Application

Related technologies: High Frequency Ultrasound Imaging

Get more info

Miroslav Vecheta

Support Specialist

Miroslav

Vecheta

+420 737 202 127

Send Message

Brand profile

VisualSonics FujiFilm

FujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research.

Related products

A new and innovative platform combining ultra high-frequency ultrasound imaging, quantification and education

show detail

Vevo LAZR-X combines high frequency ultrasound and photoacoustics into one platform for high resolution anatomical, functional and molecular imaging

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey