Accelerate to Discover

Back to filter

Related topics

Registering FDG/PET mouse and AMYViD/PET-CT rat studies to brain VOI atlases

Bruker Biospin

May 22, 2018

Preclinical NeuroPET is employed widely in studies of stroke, ischemia, addiction and eurodegenerative diseases. In...

Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation

Etaluma

May 21, 2018

Adverse tissue responses to metal wear and corrosion products from CoCr alloy implants remain a great challenge to...

New protocol: Analyze small extracellular RNAs with PippinHT

Sage Science

May 18, 2018

We’re pleased to see that PippinHT is featured heavily in the protocol for DNA sizing steps following PCR...

Genoox, Bionano collaborate to enhance the detection of pathogenic SVs

BioNano Genomics

May 14, 2018

Bionano is now working with the global health company Genoox to develop a genome informatics workflow to integrate and...

May 23, 2018

Outstanding return on investment with the xxpress qPCR thermal cycler

BJS Biotechnologies

May 10, 2018

Find out just how much money you could save by switching to the xxpress qPCR thermal cycler,visit the cost savings...

AVATAR Improves transfection efficiency with high viability

Xcell Biosciences

May 9, 2018

AVATAR lets you create any cell type even novel ones, with efficient transfection that improves reprogramming rates...

Creating a bold new future in ultrasound and photoacoustics

VisualSonics FujiFilm

May 4, 2018

Fujifilm VisualSonics has been chosen as one of the top 10 visualization solution providers in the field of developing...

May 23, 2018

Bronchoscopic confocal fluorescence microscopy for in vivo assessment of free-breathing mice

Mauna Kea Technologies

May 3, 2018

Respiratory diseases with pulmonary infections resulting over 3.5 million deaths per year. Preclinical research in...

Show all topics (10)

In vivo fluorescence imaging in mouse models of metastatic pheochromocytomas and paragangliomas

Mar 6, 2017

Pheochromocytomas (PHEOs) and extra-adrenal paragangliomas (PGLs) are rare adrenaline-producing tumors. The two tumor types are closely related and are distinguished primarily by their location: pheochromocytomas occur in the center of the adrenal glands while extra-adrenal paragangliomas originate in the paraganglia of the sympathetic nervous system (most commonly in the abdomen). Extra-adrenal paragangliomas are less common, but more likely to be malignant, than pheochromocytomas.
Diagnosis of metastatic PHEOs/PGLs is difficult and tends to rely on identification of adrenaline/noradrenaline production in areas where adrenaline/noradrenaline is not normally produced. Furthermore, such metastases are notoriously difficult to treat. A variety of chemotherapy combinations and radiotherapy are used as palliative treatment, but complete remission is rare.
Consequently, the mouse pheochromocytoma mCherry tumor allograft model was developed, which is functionally similar to human PHEO/PGLs. This mouse model has recently been used to assess the value of the [177Lu]Lu-DOTA-(Tyr3)octreotate (DOTATATE), a labeled somatostatin receptor analog, as a targeted therapy for metastatic PHEO/PGLs in man. And this study confirms that the mCherry model is a uniquely powerful tool for evaluating therapeutic or diagnostic agents that specifically target the somatostatin-2 receptor.

Read more

 

Scientific paper
Application

Get more info

Miroslav Vecheta

Support Specialist

Miroslav

Vecheta

+420 737 202 127

Send Message

Brand profile

Bruker Biospin

Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.

Related products

With Fluorescence, Luminescence, Radioisotopic and Radiographic Imaging, Xtreme provides the ultimate combination of sensitivity, speed and flexibility

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey