Accelerate to discover

Back to filter

Related topics

Magnetic resonance elastography techniques and preclinical applications

Bruker Biospin

Sep 14, 2021

It has been known for centuries that tissue stiffness can change in the presence of disease, but quantifying such...

See What's Possible with the PippinHT

Sage Science

Sep 14, 2021

Programmable DNA size selection enables new discoveries by helping optimize the library detected by a sequencer. That’s...

Ex Vivo dental imaging is directly translatable to the clinic

Bruker Biospin

Sep 14, 2021

Although patients are too large in size for preclinical microCT scanners, it still has a big significance in clinical...

IncuCyte live cell analysis system for 3D Organoids discovery

Sartorius & Essen BioScience

Sep 10, 2021

Live-Cell Analysis has revolutionized numerous studies, with a wide selection of applications namely 3D Tumour Spheroid...

Sep 20, 2021

Blood-Brain Barrier (BBB) - Pathophysiology in ischemic stroke

RWD

Aug 27, 2021

In-depth Understanding of Blood-Brain Barrier (BBB)

Introducing New Aura 4.0 software

Spectral Instruments Imaging

Aug 27, 2021

With new features for both acquisition & analysis Aura Software enables you to capture and analyze your data quickly,...

Micro-CT user meeting 2021

Bruker Biospin

Aug 19, 2021

Year after year, the Micro-CT User meeting showcases state-of-the-art applications in both life and material sciences,...

Sep 20, 2021

Comparison of gamma and x-ray irradiation results

Precision X-Ray

Aug 12, 2021

Biological effects of Cs-137 and X-ray irradiators are comparable with regards to reconstitution chimerism in normal...

Show all topics (10)

In vivo fluorescence imaging in mouse models of metastatic pheochromocytomas and paragangliomas

Mar 6, 2017

Pheochromocytomas (PHEOs) and extra-adrenal paragangliomas (PGLs) are rare adrenaline-producing tumors. The two tumor types are closely related and are distinguished primarily by their location: pheochromocytomas occur in the center of the adrenal glands while extra-adrenal paragangliomas originate in the paraganglia of the sympathetic nervous system (most commonly in the abdomen). Extra-adrenal paragangliomas are less common, but more likely to be malignant, than pheochromocytomas.
Diagnosis of metastatic PHEOs/PGLs is difficult and tends to rely on identification of adrenaline/noradrenaline production in areas where adrenaline/noradrenaline is not normally produced. Furthermore, such metastases are notoriously difficult to treat. A variety of chemotherapy combinations and radiotherapy are used as palliative treatment, but complete remission is rare.
Consequently, the mouse pheochromocytoma mCherry tumor allograft model was developed, which is functionally similar to human PHEO/PGLs. This mouse model has recently been used to assess the value of the [177Lu]Lu-DOTA-(Tyr3)octreotate (DOTATATE), a labeled somatostatin receptor analog, as a targeted therapy for metastatic PHEO/PGLs in man. And this study confirms that the mCherry model is a uniquely powerful tool for evaluating therapeutic or diagnostic agents that specifically target the somatostatin-2 receptor.

Read more

 

Scientific paper
Application

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 255 700 886

Send Message

Brand profile

Bruker Biospin

Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey