Accelerate to discover

Back to filter

Related topics

Cytek webinar : Evaluating Spectral Cytometry for Immune Profiling in Viral Disease

Cytek Biosciences

Apr 19, 2021

In conventional fluorescence cytometry, each fluorophore in a panel is measured in a target detector, through the use...

Observe the movement of live cells that make up living tissue in vivo

IVIM Technology

Apr 8, 2021

IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up...

Unleash Your Illumina Sequencer with TELL-Seq Linked Reads

Sage Science

Mar 24, 2021

Sage Science distributes universal sequencing technology´s TELL-Seq linked-read NGS library prep kits used with very...

A real time-saver, accurate cell counting in 15 seconds with C100 counter

RWD

Mar 17, 2021

Cell counters are tools for counting live and/or dead cells in a culture. Any researcher who works in a cell culture...

Apr 20, 2021

Innovation never takes a break with IncuCyte

Sartorius

Mar 11, 2021

Analyze your cells for days, weeks or even months as they sit stationary in the stable environment of your tissue...

ACCELA Educational webinar series : Cytek Aurora in action, how to easily resolve highly overlapping dyes ?

Cytek Biosciences

Mar 8, 2021

During this webinar, presented by Riccardo Pasculli, Head of Application Support @ ACCELA, we will cover: technology...

Preclinical lung imaging offers effective evaluation of drug candidates

Bruker Biospin

Mar 1, 2021

The incidence of respiratory disease is increasing throughout the world, and the demand for safe, effective drugs to...

Apr 20, 2021

Towards silent and distortion-free fMRI with Zero Echo Time MRI

Bruker Biospin

Feb 9, 2021

By using fast imaging techniques capable of scanning large brain regions within short durations, continuous snapshots...

Show all topics (10)

In-vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography

Feb 27, 2017

Muscle atrophy is a widespread ill condition occurring during inactivity, aging, and various diseases, including neuromuscular disorders, cancer, bacterial and viral infections, chronic lung and kidney diseases, diabetes, and drug side effects. The loss of muscle mass and function can reduce quality of life and increase morbidity and mortality. While exercise is today the only recognized counteracting measure to slow atrophy, a number of studies in the last decade have shed light on the underlying molecular mechanisms, paving the way for drug development. This later will require preclinical models and associated powerful techniques to evaluate trial outcomes. To date the measure of muscle atrophy in animal disease models usually requires animal sacrifice in order to weigh excised muscles and perform histological and biochemical studies. This approach is invasive and expensive involving the use of a large number of animals to obtain significant results. Therefore realizing a new, non invasive method allowing longitudinal in vivo evaluation of muscle atrophy would become an invaluable tool.
The ultrasonography is a non invasive diagnostic imaging technique based on the application of ultrasounds, which is widely used for various medical applications, including the quantification of structural and functional changes in skeletal muscles. In the recent years, the technique has been adapted to the preclinical setting, owing to the development of equipment able to work at high frequencies, from 40 to 100 MHz, and therefore suitable for high-resolution ultrasound evaluations on small animals such as rodents. While ultrasonography has been mostly used for tumor and cardiac investigations, there are currently only a few reports relative to its use for the evaluation of skeletal muscle structural and functional parameters in rodents. The aim of this study was to develop a non-invasive method to evaluate in vivo the volume variation of hindlimb muscle of rats, as a measure of skeletal muscle atrophy, using ultrasonography. To achieve this goal, there was performed a longitudinal ultrasonographic study of rat soleus (Sol) and gastrocnemius lateralis (Gas) muscle volume variation during a 14-days hindlimb-unloading (HU) period, which is a widely acknowledged model of disuse-induced muscle atrophy.

Read more

Scientific paper
Technical breakthrough

Related technologies: High frequency ultrasound imaging

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 255 700 886

Send Message

Brand profile

VisualSonics FujiFilm

FujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research.

Related products

High-frequency ultrasound, designed for preclinical cardiac researchers

show detail

The first high-frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode

show detail

A new and innovative platform combining ultra high-frequency ultrasound imaging, quantification and education

show detail

Photoacoustics is a ground-breaking, real time imaging modality for visualizing small animal anatomy and analyzing function in vivo and non-invasively

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey