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Bruker announces acquisition of preclinical and molecular imaging research software provider PMOD
Aug 19, 2019
The PMOD software is widely used for the analysis of positron emission tomography (PET) studies in neurology,...
Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome
Aug 16, 2019
The BluePippin was used for High Pass DNA size selection prior to library construction. ONT Promethion was used for...
Fluxion Biosciences launches custom liquid biopsy NGS panel development
Aug 14, 2019
Fluxion a leading developer of precision solutions for life science research and diagnostics, announced that can...
Superior flow cytometry data with NEW Curiox Laminar Wash systems - centrifuge - less washing
Aug 12, 2019
The Laminar Wash technology provides an advantage to scientists in processing suspension cells for flow cytometry....
Next-generation cytogenetics is here
Aug 9, 2019
On ESHG 2019 conference several oral and poster presentations compared Bionano optical mapping to clinical cytogenetics...
Electroporation using Lumascope: A sustainable method for Adipogenous Mesenchymal Stem Cells
Aug 7, 2019
Human mesenchymal stem cells derived from adipose tissue (AD-hMSCs) represent a promising source for tissue engineering...
The best way to fragment DNA for genomic and paired end library construction
Aug 5, 2019
Digilab NextGen Shear DNA Shearing offers the simplest, most reproducible, and most controllable method available for...
Software Update: Bionano releases a new pipeline for low Aalelic fraction SVs
Jul 31, 2019
Bionano Solve v3.4 is a major update that introduces an entirely new pipeline to detect SVs at low allelic fraction and...
Dec 6, 2018
To facilitate an expanded application, researchers present a scalable and high-throughput strategy tosimultaneously target multiple endogenous proteins in living cells with micro- to nanometer resolution. Forintracellular protein labeling, they advanced nanobodies by site-specific and stoichiometric attachment ofbright organicfluorophores. Their fast andfine-tuned intracellular transfer by microfluidic cell squeezingenabled high-throughput delivery with less than 10% dead cells. This strategy allowed for the dual-colorimaging of distinct endogenous cellular structures, and culminated in super-resolution imaging of nativeprotein networks in genetically non-modified living cells. The simultaneous delivery of multipleengineered nanobodies does not only offer exciting prospects for multiplexed imaging of endogenousprotein, but also holds potential for visualizing native cellular structures with unprecedented accuracy.
Related technologies: Time-lapse microscopy
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