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Small animal 13C-hyperpolarized MRI

Bruker Biospin

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13C-Hyperpolarized molecules provide a unique signature for molecular processes relevant to a range of disease...

Oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts

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Spectral Instruments Imaging

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Feb 20, 2019

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Sartorius

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The success of immune checkpoint blockade adds new therapeutic category to Cancers are the most heterogenous group of...

CT‐analyzer plug‐ins: ROI shrink‐wrap and primitive ROI

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The ROI shrink‐wrap gives the possibility to automatically generate a region‐of‐interest by adapting to the shape of...

ACEA Biosciences launch xCELLigence RTCA software Pro for immunotherapy applications

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Cellular stress induces erythrocyte assembly and promotes microangiopathy

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Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...

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Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies

Dec 6, 2018

To facilitate an expanded application, researchers present a scalable and high-throughput strategy tosimultaneously target multiple endogenous proteins in living cells with micro- to nanometer resolution. Forintracellular protein labeling, they advanced nanobodies by site-specific and stoichiometric attachment ofbright organicfluorophores. Their fast andfine-tuned intracellular transfer by microfluidic cell squeezingenabled high-throughput delivery with less than 10% dead cells. This strategy allowed for the dual-colorimaging of distinct endogenous cellular structures, and culminated in super-resolution imaging of nativeprotein networks in genetically non-modified living cells. The simultaneous delivery of multipleengineered nanobodies does not only offer exciting prospects for multiplexed imaging of endogenousprotein, but also holds potential for visualizing native cellular structures with unprecedented accuracy.

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