Accelerate to discover

Back to filter

Related topics

Identify the quality of any protein in 3 minutes using microliters of sample with Tycho

NanoTemper

Jul 19, 2019

Tycho tells you so much about the quality of your protein. It tells you about presence, purity, concentration,...

Expanding patient tumor samples has never been so easy - Discover AVATAR

Xcell Biosciences

Jul 10, 2019

The AVATAR Cell Control System lets you fine-tune oxygen and pressure to cater culture conditions to your cell type of...

Take advantage of 4D mode

VisualSonics FujiFilm

Jul 4, 2019

Cutting edgce cardiovascular research demands cutting edge technology. 4D imaging brings together dynamic motion and 3D...

CQ1 confocal quantitative image cytometer: fighting colon cancer with killer cells

Yokogawa

Jul 2, 2019

Genetically modified immune cells can successfully destroy colon cancer cells. This has been demonstrated for the first...

Jul 21, 2019

Assessment of angiotensin II-induced mouse models of abdominal aortic aneurysm

VisualSonics FujiFilm

Jun 28, 2019

Are you working with high ultrasound imaging and are you interesting in progression/ regression of abdominal aortic...

Bionano introduce new SP blood and cell culture DNA isolation kit

BioNano Genomics

Jun 26, 2019

This Bionano prep SP blood and cell culture DNA isolation kit, can provide ultra-high molecular weight (UHMW) gDNA in...

Breast cancer‐derived exosomes reflect the cell of origin phenotype

IZON

Jun 24, 2019

The qNano Gold measures particles using the Tunable Resistive Pulse Sensing (TRPS) principle. TRPS is the most powerful...

Jul 21, 2019

Transcutaneous implantation of valproic acid-encapsulated

Spectral Instruments Imaging

Jun 21, 2019

The interest in alternative material systems and delivery methods for treatment of androgenetic alopecia has been...

Show all topics (10)

Monitoring of blood vessel density may facilitate early diagnosis of lymph node metastasis

Jun 26, 2017

Time-dependent alterations in the ultrasonography characteristics of lymph nodes during early-stage metastasis have not been compared with those of tumor-draining lymph nodes that do not develop tumor; this is partly due to the absence of an appropriate experimental model. In a previous study of lymph nodes with experimental early-stage metastasis, we used contrast-enhanced high-frequency ultrasound to demonstrate that an increase in lymph node blood vessel density preceded any changes in lymph node volume. In the present study, we used an experimental model of lymph node metastasis in which tumor cells metastasized from the subiliac lymph node to the proper axillary lymph node (the tumor-draining lymph node). We utilized contrast-enhanced high-frequency ultrasound to perform a longitudinal analysis of tumor-draining lymph nodes, comparing those at an early-stage of metastasis with those that did not develop detectable metastasis. We found that the normalized blood vessel density of an early-stage metastatic lymph node exhibited a progressive rise, whereas that of a tumor-draining lymph node not containing tumor began to increase later. For both types of lymph nodes, the normalized blood vessel density on the final day of experiments showed a trend towards being higher than that measured in controls. We further found that mice with an initially low value for lymph node blood vessel density subsequently showed a larger increase in the blood vessel density of the metastatic lymph node; this differed significantly from measurements in controls. The present study indicates that a longitudinal analysis of the blood vessel densities of tumor-draining lymph nodes, made using contrast-enhanced high-frequency ultrasound imaging, may be a potentially promising method for detecting early-stage lymph node metastasis in selected patients. Furthermore, our findings suggest that tumor in an upstream lymph node may induce alteration of the vascular structures in draining lymph nodes that do not contain tumor.

Read more

Scientific paper
Application

Related technologies: High frequency ultrasound imaging

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 255 700 886

Send Message

Brand profile

VisualSonics FujiFilm

FujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research.

Related products

The first high-frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode

show detail

A new and innovative platform combining ultra high-frequency ultrasound imaging, quantification and education

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey