Accelerate to discover

Back to filter

Related topics

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs

Fluxion Biosciences

Oct 12, 2018

Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition,...

Target large genomic regions with 10x genomics + SageHLS

Sage Science

Oct 9, 2018

With customized Cas9 nucleases, scientists can now isolate specific large genomic DNA fragments with the SageHLS...

Coy anaerobic chambers #1 choice in microbiology

COY laboratory products

Oct 5, 2018

Used for over 40 years in anaerobic microbiology research, COY chambers are also critical to many other research areas...

Understanding subtle cardiac changes

VisualSonics FujiFilm

Oct 3, 2018

Are you working with high ultrasound imaging and are you interesting in VevoStrain application and specific changes in...

Oct 15, 2018

EasyTEL+ unique digital platform for single or group-housed subjects e

emka TECHNOLOGIES

Sep 24, 2018

EMKA announced major enhancements of its easyTEL+ digital implanted telemetry. No more antennas inside cages,...

Quantitative characterization of metaphase cellular events using 3D imaging cellular events 

Yokogawa

Sep 20, 2018

In conventional monolayer cell culture systems, cell nuclei show dynamic and cyclic changes in theirshape and height....

A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy

Spectral Instruments Imaging

Sep 18, 2018

A polymeric conjugate, composed of a carboxymethyl dextran (CMD) as the backbone and ovalbumin (OVA) as a model foreign...

Oct 15, 2018

Adenovirus type B detection using the xxpress qPCR thermal cycler

BJS Biotechnologies

Sep 17, 2018

The ultrafast xxpress qPCR thermal cycler through performing standard dilution series and multiplex qPCR experiments is...

Show all topics (10)

Monitoring of blood vessel density may facilitate early diagnosis of lymph node metastasis

Jun 26, 2017

Time-dependent alterations in the ultrasonography characteristics of lymph nodes during early-stage metastasis have not been compared with those of tumor-draining lymph nodes that do not develop tumor; this is partly due to the absence of an appropriate experimental model. In a previous study of lymph nodes with experimental early-stage metastasis, we used contrast-enhanced high-frequency ultrasound to demonstrate that an increase in lymph node blood vessel density preceded any changes in lymph node volume. In the present study, we used an experimental model of lymph node metastasis in which tumor cells metastasized from the subiliac lymph node to the proper axillary lymph node (the tumor-draining lymph node). We utilized contrast-enhanced high-frequency ultrasound to perform a longitudinal analysis of tumor-draining lymph nodes, comparing those at an early-stage of metastasis with those that did not develop detectable metastasis. We found that the normalized blood vessel density of an early-stage metastatic lymph node exhibited a progressive rise, whereas that of a tumor-draining lymph node not containing tumor began to increase later. For both types of lymph nodes, the normalized blood vessel density on the final day of experiments showed a trend towards being higher than that measured in controls. We further found that mice with an initially low value for lymph node blood vessel density subsequently showed a larger increase in the blood vessel density of the metastatic lymph node; this differed significantly from measurements in controls. The present study indicates that a longitudinal analysis of the blood vessel densities of tumor-draining lymph nodes, made using contrast-enhanced high-frequency ultrasound imaging, may be a potentially promising method for detecting early-stage lymph node metastasis in selected patients. Furthermore, our findings suggest that tumor in an upstream lymph node may induce alteration of the vascular structures in draining lymph nodes that do not contain tumor.

Read more

Scientific paper
Application

Related technologies: High frequency ultrasound imaging

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 737 202 127

Send Message

Brand profile

VisualSonics FujiFilm

FujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research.

Related products

The first high-frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode

show detail

A new and innovative platform combining ultra high-frequency ultrasound imaging, quantification and education

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey