Accelerate to discover

Back to filter

Related topics

Cardiomyocyte isolation using Cellenion’s cellenONE instrument

Cellenion

Mar 24, 2023

The cellenONE platform is ideal for the isolation of fragile and heterogeneous cell size populations, such as...

Introducing Cytek Human Leukocyte Kit, the first ever 15-color lyse no-wash assay

Cytek Biosciences

Mar 13, 2023

This kit has been designed to enumerate all major leukocyte subsets and it mirrors and expands on those identified in a...

Immunofluorescence Imaging for Rare Cell Detection with CyteFinder II

RareCyte

Mar 7, 2023

CyteFinder II Instruments are high speed, whole slide imaging systems with options for liquid biopsy analysis and...

New Kit for Bacterial analysis expands capability of Guava Muse flow cytometer

Luminex

Feb 20, 2023

With the Guava Muse cell analyzer, you can now achieve highly quantitative results at a fraction of the price, effort,...

Apr 2, 2023

CellRad+ benchtop X-Ray irradiator

Precision X-Ray

Dec 9, 2022

New CellRad+ benchtop irradiator for biological samples is coming with higher voltage and continue exposure for 180...

Introducing Cytek Cloud

Cytek Biosciences

Dec 1, 2022

Cytek Cloud is the new digital ecosystem that supports full spectrum flow cytometry research from panel design to data...

See More, Sort More with Cytek Full Spectrum Systems

Cytek Biosciences

Nov 28, 2022

Still wondering whether to join the shift to full spectrum cytometry?  Easily transfer assays from your Cytek Northern...

Apr 2, 2023

Introducing MARS system : revolutionary solution for your workflow of cell separation and enrichment

Applied Cells

Oct 7, 2022

The MARS family of instruments provides a breakthrough solution to complete the workflow of cell separation and...

Show all topics (10)

New ACEA kit for B cell killing

Aug 1, 2016

ACEA Biosciences, a pioneer in the development of high performance cell analysis platforms including the xCELLigence Real-Time Cell Analyzer (RTCA) instruments and NovoCyte flow cytometers, is introducing an immunotherapy kit for in vitro monitoring and quantification of effector-mediated B cell killing. This kit enables continuous real-time monitoring of B cell lymphomas as they are exposed to diverse immunotherapy approaches including NK cells, T cells, CARTs, oncolytic virus, checkpoint inhibitors, bispecific antibodies, BiTEs, etc. The major distinguishing features of this technology include enhanced sensitivity, the preclusion of labels, simple workflow and, importantly, continuous kinetic measurement of B cell cytolysis. This B cell-specific kit is the first in a series of xCELLigence immunotherapy-focused kits that ACEA will be launching in the coming months.

The utility of impedance-based xCELLigence Real-Time Cell Analysis (RTCA) for probing the efficacy of immunotherapies targeting solid/adherent cancers has been firmly established over the past decade. However, ~10% of all cancers are liquid in nature, are non-adherent and therefore cannot be directly monitored by the standard impedance assay. The B Cell Killing Assay Kit contains reagents which enable B cells to be selectively immobilized in the well bottoms of ACEA’s electronic microtiter plates. Addition of effector cells (NK, T, CART) on top of immobilized B cells results in cytolysis of target cells in an effector concentration-dependent manner. The continuous acquisition of impedance data for each well of the electronic plate allows the generation of real-time killing curves for multiple conditions simultaneously.

Dr. Yama Abassi, Vice President of ACEA Biosciences, noted that “The xCELLigence instruments provide a quantitative kinetic assessment of immune cell-mediated killing of both solid and liquid tumor cells under label-free conditions.” He further stated that “This functional assay is currently being used for evaluating/optimizing combination therapies, and for the development of adoptive cell therapies and engineered antibodies. Beyond the arena of R&D, we envision xCELLigence being utilized as a quality control assay for manufactured immuno-oncology therapies.”

Product news

Related technologies: Conventional flow cytometry

Brand profile

Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

Related products

The best in class personalized flow cytometer

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey