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Top 10 Pharma companies have chosen CYTEK for their flow cytometry facility

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6 of Top 10 Pharma Companies (Based on total group revenues) have chosen CYTEK - full spectrum flow cytometer for their...

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Elevated NSD3 histone methylation activity drives squamous cell lung cancer

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PMOD Virtual User Meeting

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Jun 7, 2021

We look forward to welcoming many of our users to 2021 PMOD User Meeting. The theme of our PMOD User Meeting will be...

IncuCyte webinar recording: How to measure Immune Cell Killing of Tumor Cells effectively

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White Paper: Immunophenotyping Rare Immune Cells with Laminar Wash AUTO System

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Non-invasive fluorescence imaging of infiltration in a mouse model of acute lung inflammation

Nov 29, 2016

The presence of bacterial endotoxin, lipopolysaccharide (LPS) in the lung can induce a major inflammatory response leading to acute lung injury. LPS is thought to immediately activate resident macrophages, leading to the production of various cytokines, including TNF-α. This will, in turn, prompt the recruitment of inflammatory cells, mainly neutrophils, into the lung through increases in capillary permeability and alveolar edema.1 Neutrophil infiltration into the lung can be monitored by certain, activatable (smart) fluorescent probes. This study evaluates the use of an activatable optical probe that is
optically silent upon inhalation and produces a fluorescent signal only after selective cleavage by the serine protease elastase produced by neutrophils.

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