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Theranostics: From Mice to Men and Back

MOLECUBES

Jun 25, 2024

Recorded webinar
Presenters: Prof. Dr. Ken Herrmann and Prof. Dr. Katharina Lückerath – Moderator: Hannah Notebaert

Orion 2024 AACR poster: 17-plex single-step stain and imaging of cell Lung Carcinoma

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Bruker Biospin

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MRI images were obtained using the 9.4T Bruker BioSpec system, equipped with 40 mm 1H quadrature volume resonator, and...

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Spectral Instruments Imaging

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Disha Moholkar of University of Louisville's Gupta Lab
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...

Emulate in vivo conditions – introduce shear flow to your experiments with BioFlux system

Cell Microsystems

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Most research is still conducted in vitro without the presence of flow. We use the BioFlux System to give you the...

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High-frequency Ultrasound System For Preclinical Imaging

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The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...

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Non-invasive, in vivo bioluminescence imaging of myeloperoxidase activity in a psoriasis-like mouse

Nov 1, 2016

Psoriasis is a chronic inflammatory disease affecting 1–3 % of the general population. Traditional systemic therapies for psoriasis, such as methotrexate, have a potential for long-term toxicity and may not always provide sufficient improvement of the condition.
In a recent study by van der Fits et al. a mouse model of dermatitis closely resembling human psoriasis was obtained by the topical application of Imiquimod (IMQ) to mouse ear skin. IMQ, linked to the IL-23/IL-17 axis, can function as a toll-like receptor 7/8 (TLR7/8) ligand and initiate a potent innate immune system response. Mouse skin lesions showed increased epidermal proliferation, abnormal differentiation of keratinocytes, epidermal accumulation of neutrophils in micro-abcesses, neo-angiogenesis, and infiltrates consisting of CD4(+) T cells, CD11c(+) dendritic cells, and plasmacytoid dendritic cells.
In the mouse dermatitis study presented here, in vivo phagocyte-mediated myeloperoxydase (MPO) activity was monitored non-invasively by detecting bioluminescent signal resulting from MPO-specific luminol catabolism. MPOluminol bioluminescence signal is known to be co-localized with histological sites of inflammation as well as infiltration of neutrophils and activated eosinophils.

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