Accelerate to discover

Back to filter

Related topics

Webinar: Join us for an In-Depth Look at the Revolutionary Small Animal Radiotherapy System at STTARR

Precision X-Ray

Aug 17, 2023

Register for an engaging webinar led by Naz Chaudary, Ph.D., and Research Technician, Alex Wang from the...

Optimizing Gene Expression with Bioluminescence & the piggyBac System

Spectral Instruments Imaging

Aug 15, 2023

Discover how bioluminescence imaging & the piggyBac gene editing system optimize & track gene expression in mouse...

High-plex immunofluorescence imaging and traditional histology of the same tissue section

RareCyte

Aug 7, 2023

RareCyte Orion’ platform has been used for collecting H&E and high-plex immunofluorescence images from the same cells...

Drive key insights and discoveries with NEW Live Cell Analysis applications for eSight system

Agilent technologies

Aug 2, 2023

eSight is now powerful like never before. Learn more about new dedicated application modules for live-cell analysis: 3D...

Sep 30, 2023

Single cell-resolution in situ sequencing elucidates spatial dynamics of multiple sclerosis

Vizgen

Jul 14, 2023

MERFISH integrates spatial transcriptomics technology with high resolution spatial imaging, fluidics, image processing,...

MARS - High Efficiency Separation of CD34+ HSC from Mobilized Blood

Applied Cells

Jul 12, 2023

MARS platform provides an easy and cost-effective protocol for CD34+ cell isolation. Single pass CD34+ HSC enrichment...

43 markers, ONE tube : Impress yourself with Cytek Aurora Spectral Cytometer

Cytek Biosciences

Jul 11, 2023

Using Cytek full spectrum flow cytometry, scientists at Hamad Medical Corporation, developed a 43 color panel to...

Sep 30, 2023

InAlyzer - The technology chosen by NASA

MEDIKORS

Jul 10, 2023

MEDIKORS's InAlyzer was finally selected as the equipment to be used for NASA's space environment biological research

Show all topics (10)

Non-invasive, in vivo bioluminescence imaging of myeloperoxidase activity in a psoriasis-like mouse

Nov 1, 2016

Psoriasis is a chronic inflammatory disease affecting 1–3 % of the general population. Traditional systemic therapies for psoriasis, such as methotrexate, have a potential for long-term toxicity and may not always provide sufficient improvement of the condition.
In a recent study by van der Fits et al. a mouse model of dermatitis closely resembling human psoriasis was obtained by the topical application of Imiquimod (IMQ) to mouse ear skin. IMQ, linked to the IL-23/IL-17 axis, can function as a toll-like receptor 7/8 (TLR7/8) ligand and initiate a potent innate immune system response. Mouse skin lesions showed increased epidermal proliferation, abnormal differentiation of keratinocytes, epidermal accumulation of neutrophils in micro-abcesses, neo-angiogenesis, and infiltrates consisting of CD4(+) T cells, CD11c(+) dendritic cells, and plasmacytoid dendritic cells.
In the mouse dermatitis study presented here, in vivo phagocyte-mediated myeloperoxydase (MPO) activity was monitored non-invasively by detecting bioluminescent signal resulting from MPO-specific luminol catabolism. MPOluminol bioluminescence signal is known to be co-localized with histological sites of inflammation as well as infiltration of neutrophils and activated eosinophils.

Read more

Scientific paper
Application

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 210 323 421

Send Message

Brand profile

Bruker Biospin

Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey