Accelerate to discover

Back to filter

Related topics

Centrifugation of suspension cells is a problem!

Curiox

Jul 8, 2020

Do you think that centrifuging cells at 500 x g is not going to cause issues? Moreover, sample prep involving...

IncuCyte webinar: Advances in 3D cell models for cancer biology

Sartorius

Jul 1, 2020

Get answers to your questions on 3D spheroid-based drug discovery, organoid research and working with advanced cell...

Bruker MicroCT systems supporting quality control for refurbished FFP masks

Bruker Biospin

Jun 29, 2020

In the effort to tackle the coronavirus pandemic, Bruker is proud that its instruments are being used to ensure quality...

Advance your Neuro-Oncology applications with IncuCyte

Sartorius

Jun 25, 2020

Neuro-oncology research can benefit from robust translational in vitro models to gain greater understanding of brain...

Jul 11, 2020

MicroCT Applications in Lung research and Immunology

Bruker Biospin

Jun 22, 2020

The ability to monitore and quantitate lung disease in real time is an advantage to using small animal microCT. Also,...

Imaging Extracellular Vescicles with super-resolution microscopy

ONI

Jun 18, 2020

Extracellular vesicles (EVs) play key roles in cell-to-cell communication. EVs can cross biological barriers (such as...

The Role of Micro-CT in Imaging Breast Cancer Specimens

Bruker Biospin

Jun 17, 2020

The goal of breast cancer surgery is to remove all of the cancer with a minimum of normal tissue, but absence of full...

Jul 11, 2020

Cytek Northern Lights: 41 parameters with 3 lasers only

Cytek Biosciences

Jun 12, 2020

Cytek Biosciences Northern Lights incorporates the same innovations as the Aurora, but at a lower price point. It...

Show all topics (10)

Real-time monitoring of adverse effects on cardiomyocytes derived from Embryonic Stem Cells

Nov 3, 2016

Up to now, the pre-clinical analysis of all these parameters has been hampered by the lack of both (1) a standardized, pure cardiac cell and tissue model to monitor cardiac-specific toxicity and (2) a suitable technology-platform for continuous, label-free analysis of cell function and integrity. These impediments are now addressed by the xCELLigence Real-Time Cell Analyzer (RTCA) System, in combination with pure cardiomyocytes generated from mouse embryonic stem cells.

To predict the pharmacological and toxicological effects of a drug, scientists use either recombinant cell systems such as cell lines expressing specific ion channels or primary cardiomyocytes prepared from, for example, neonatal rats. The disadvantages of these systems are that recombinant cell lines lack the physiological ion channel environment and functional humoral regulation. Freshly isolated primary cardiomyocytes, although showing physio-logical properties, are costly and time consuming to produce and difficult to standardize. Furthermore, the possibility of contamination with other cell types increases the variability of data and reduces the reliability of test results.

Read more

Scientific paper
Application
Product news

Related technologies: Real-time, label free cell analysis

Get more info

Riccardo Pasculli

Head of application support

Riccardo

Pasculli

+420 731 127 717

Send Message

Brand profile

Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

Related products

Cardio Instrument is a high-resolution system for label-free-dual-mode monitoring of cardiomyocyte and cardiotoxicity testing

show detail

The new CardioECR system combines impedance and Multi Electrode Array (MEA) technology with a pacing function

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey