Recent publication of in-vivo two-photon intravital imaging study targeting mouse kidney

Chronic kidney disease (CKD) is one of the most common renal diseases manifested
by gradual loss of kidney function with no symptoms in the early stage. The underlying
mechanism in the pathogenesis of CKD with various causes such as high blood pressure, diabetes,
high cholesterol, and kidney infection is not well understood. In vivo longitudinal repetitive
cellular-level observation of the kidney of the CKD animal model can provide novel insights
to diagnose and treat the CKD by visualizing the dynamically changing pathophysiology of
CKD with its progression over time. In this study, using two-photon intravital microscopy with
a single 920 nm fixed-wavelength fs-pulsed laser, we longitudinally and repetitively observed
the kidney of an adenine diet-induced CKD mouse model for 30 days.

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Article was published on 1st April 2023 in Biomedical Optics Express, Vol. 14, No. 4.