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High-frequency Ultrasound System For Preclinical Imaging

S-Sharp

May 13, 2024

The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...

“Range+T “ for Tight Sizing of HMW Libraries

Sage Science

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We decided to do a deep dive into Range+T to get a better handle the method, and to develop best practices for using...

April 2024 publication revealing benefits of using intravital microscopy in trascriptomics studies

IVIM Technology

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Transcriptional activation of Bmal1 drives the inflammatory activity of monocytes by modulating mitochondrial unfolded...

Minimal information for studies of extracellular vesicles (MISEV2023)

IZON

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MISEV2023 is intended to aid any and all EV researchers: from those just starting their EV journey to more established...

May 25, 2024

Omics Studies of Tumor Cells under Microgravity Conditions

CelVivo

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It is important for the analysis of data from space experiments to distinguish unspecific stress reactions from...

Column-Free CD14+ Monocyte Isolation using 50nm Superparamagentic Beads on MARS® Bar

Applied Cells

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The MARS® Bar Magnetic Separation Platform is a closed and automated isolation for cell therapy development and...

Spatial and temporal profiling of the complement system uncovered novel functions of the alternative

Vizgen

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Mounting evidence implicated the classical complement pathway (CP) in normal brain development, and the pathogenesis of...

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The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging

Precision X-Ray

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Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging...

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Single cell-resolution in situ sequencing elucidates spatial dynamics of multiple sclerosis

Jul 14, 2023

In this study using MERSCOPE platform, we demonstrated that disease-associated (DA) glia are dynamic and induced independently of lesions, preceding their formation. Singlecell spatial analysis of human archival MS spinal cord confirmed differential distribution of DAglia, enabled deconvolution of active and inactive lesions into sub-compartments, and identification of new lesion areas. By establishing a spatial resource of mouse and human MS neuropathology at a single-cell resolution, our study unveils the intricate cellular dynamics underlying MS disease evolution.

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Related technologies: Spatial Transcriptomics

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Vizgen

MERFISH is a massively multiplexed single-molecule imaging technology for spatially resolved transcriptomics capable of simultaneously measuring the copy number and spatial distribution of hundreds to tens of thousands of RNA species in individual cells.

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High multiplexing, high resolution in situ platform to combine single-cell and spatial genomics analysis powered by MERFISH technology.

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