The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.
Accelerate to discover
Related topics
Advances in Leukemia research using shear flow and Bioflux system
Feb 3, 2023
Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...
Webinar: Dose Reduction and Image Enhancement in Preclinical Mouse Imaging using Deep Learning
Jan 31, 2023
In this webinar, ir. Florence Muller (Ghent University - University of Pennsylvania) is presenting two recent studies...
Advance your Spatial Biology, customize your panel design with RareCyte Orion reagents
Jan 23, 2023
Orion system, the highly multiplexed fluorescent imaging system, in combination with dedicated reagents, empower...
Extensive assessment of Cytokine production on the NovoCyte Advanteon flow cytometer
Jan 13, 2023
Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...
New installation of Cytek Aurora in Slovenia
Jan 11, 2023
2nd spectral flowcytometer Aurora from Cytek was installed at National Institute of Biology in Slovenia
Microfluidic cell sorter sample preparation for genomic assays
Dec 16, 2022
Single-cell RNA-Sequencing has led to many novel discoveries such as the detection of rare cell populations, microbial...
Dec 1, 2022
Cytek Cloud is the new digital ecosystem that supports full spectrum flow cytometry research from panel design to data...
See More, Sort More with Cytek Full Spectrum Systems
Nov 28, 2022
Still wondering whether to join the shift to full spectrum cytometry? Easily transfer assays from your Cytek Northern...
Nov 29, 2017
While extensive research has focused on soluble factors to optimize stem cell culture, conditions such as hypoxia, atmospheric pressure, and the composition and organization of the extracellular matrix are also important drivers of stem cell differentiation and cell function. However, no study to date has systematically analyzed the contribution of these factors in the maintenance and differentiation of stem cells, leading to uncertainty surrounding the extracellular factors that dictate stem cell state.To address this, Xcell Biosciences has developed a novel stem cell culturing platform, the Avatar SystemTM, which allows for tunable control of the microenvironment and uniquely offers customizable settings for oxygen and hydrostatic pressure. In a recent study, Xcell scientists analyzed human pluripotent stem cells to characterize their underlying biology and to demonstrate the utility of the Avatar system. Cells were cultured in minimally supportive media to allow stem cell state to drift. The Avatar system was used to tune environmental conditions and determine the impact of oxygen tension and pressure in guiding stem cell fate.
For this project, scientists reprogrammed primary human dermal fibroblasts via episomal expression of key stemness factors (Sox2, Nanog, and Oct4) while cultured in altered oxygen concentration (1% – 5%) and atmospheric pressure (0 PSI – 5 PSI) using the Avatar system compared to conventional culture methods. Having generated iPSCs, scientists next aimed to assess their pluripotent potential relative to the condition in which reprogramming and subsequent long term culture was performed.
Related technologies: Physiological cell culturing
Get more info
Brand profile
The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.
More info at:
www.xcellbio.com