The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.
Accelerate to discover
Related topics
The draft genome sequence of the Japanese rhinoceros beetle Trypoxylus dichotomus septentrionalis
Nov 30, 2023
The SageHLS instrument was used to size select DNA between 50-80 kb for 10X Genomics Chromium linked read analysis.
Factors Affecting Petri Dish Condensation in Tissue Culture (CU) Chambers
Nov 29, 2023
In this report, we will investigate the effects of infrared lighting, light intensity, stacking, as well as constant...
Visualization of spatial distribution of hemoglobin with various oxygen saturations in small animals
Nov 28, 2023
With the aid of our uniquely developed device and analysis software, our primary objective is to map the spatial...
A fluorescent reporter system for anaerobic thermophiles
Nov 27, 2023
Anaerobic microorganisms are key effectors for the sustainable production of biofuels and biochemicals, as they...
Vizgen webinar: spatial relationships in Developmental Biology
Nov 21, 2023
MERFISH integrates spatial transcriptomics technology with high resolution spatial imaging, In this webinar we will...
Nov 14, 2023
The xCELLigence RTCA eSight enables simultaneous real time biosensor impedance-based and...
NanoCellect webinar: Plant Potential - Gentle Cell Sorting for Enhanced Plant Biology Workflows
Nov 3, 2023
Gentle cell sorting is a useful tool to increase the efficiency of plant biology workflows that include gene...
Single Cell Deposition: the cornerstone of Flow Cytometry for cellular analysis and manipulation
Nov 2, 2023
One notable technology for harnessing the power of single cell deposition is the NanoCellect WOLF G2 Cell Sorter and N1...
Apr 16, 2018
The characterization of the tumor microenvironment includes mechanotransduction, hypoxia, acidosis, and tissue remodeling. These factors can influence the gene and protein expression of variouse cell types that make up the tumor as well as influence the selection of cells that can thrive in a given microenvironment; however, typical cancer cell culture rarely uses hypoxia and pressure onr utilizes substrates similar to the native extracellular matrix. Cancer cell lines and PBMCs differentially express immunotherapeutic targets, at low oxygen and high pressure culturing conditions, resulting in reduced expression of key drug targets.
Analysis of mRNA-seq data revealed alterations in gene expression profiles of immunotherapeutic and drug-target pathways involving CTLA-4 and AR signaling. In contrast, it was obsorved increased CD47 and CD44 expression at low oxzgen and high presure culturing conditions in cancer cell lines and immune cells. Therefore these results support the presence of physiologically-relevant drug targets in tumor cells characterized by low oxygen and high interstitial fluid preassure.
Related technologies: Physiological cell culturing
Get more info
Brand profile
The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.
More info at:
www.xcellbio.com