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Method to quantify local force distribution within biomolecular systems

LUMICKS

May 24, 2018

The journal Nano Letters has recently published the article “Quantifying Local Molecular Tension Using Intercalated DNA...

Bionano fall user workshop

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We are happy to announce the Bionano Genomics’ 2018 user workshop taking place in San Diego on October 15-16,...

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New protocol: Analyze small extracellular RNAs with PippinHT

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We’re pleased to see that PippinHT is featured heavily in the protocol for DNA sizing steps following PCR...

Genoox, Bionano collaborate to enhance the detection of pathogenic SVs

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AVATAR Improves transfection efficiency with high viability

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AVATAR lets you create any cell type even novel ones, with efficient transfection that improves reprogramming rates...

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Creating a bold new future in ultrasound and photoacoustics

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The effects of hypoxia and hydrostatic pressure in translational research

Apr 16, 2018

The characterization of the tumor microenvironment includes mechanotransduction, hypoxia, acidosis, and tissue remodeling. These factors can influence the gene and protein expression of variouse cell types that make up the tumor as well as influence the selection of cells that can thrive in a given microenvironment; however, typical cancer cell culture rarely uses hypoxia and pressure onr utilizes substrates similar to the native extracellular matrix. Cancer cell lines and PBMCs differentially express immunotherapeutic targets, at low oxygen and high pressure culturing conditions, resulting in reduced expression of key drug targets.

Analysis of mRNA-seq data revealed alterations in gene expression profiles of immunotherapeutic and drug-target pathways involving CTLA-4 and AR signaling. In contrast, it was obsorved increased CD47 and CD44 expression at low oxzgen and high presure culturing conditions in cancer cell lines and immune cells. Therefore these results support the presence of physiologically-relevant drug targets in tumor cells characterized by low oxygen and high interstitial fluid preassure.

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Xcell Biosciences

The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.

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The Avatar system can mimic the oxygen and pressure levels of human tissues

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