Targeted sequencing is currently the most promising and feasible path toward reliably uncovering common and rare variation in the human genome, both in terms of clinical feasibility and cost, when compared with whole-genome or whole-exome sequencing. Attributes such as automation, specificity and sensitivity can all have a critical impact on the overall sequencing quality and costs. RainDance offers a proven single-molecule picodroplet technology platform that allows researchers to apply the familiar gold-standard PCR technique more cost-effectively and at higher throughput than ever before using any next-generation sequencer. The streamlined workflow ensures highest quality sequence data and lowest overall cost per sample.