Presentation of both direct tumor core engraftments as well as work done on patient-derived cell-lines. The 3D power Doppler provides high quality estimates of tumor volume/vascularization and allows visualization feeding arterioles. Contrast-enhanced ultrasound permits quantification of tumor perfusion. Testing clinically relevant anti-angiogenic drugs: sunitinib, pazopanib, sorafenib, sirolimus, everolimus, and vehicle control (DMSO). Ultrasound quantifications are combined to classify patient samples as either drug sensitive or drug resistant. Results validated with histology and clinical outcomes.
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