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Discover the Celloger live-cell analyzers : miniaturized and powerful tools for every Biologist

Curiosis

Apr 5, 2024

Celloger live-cell analyzers, image and analyze your cells in real-time, inside your incubator. With its exceptional...

The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging

Precision X-Ray

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Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging...

A microthrombus-driven fixed-point cleaved nanosystem for preventing post-thrombolysis recurrence

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A thrombin-responsive and fixed-point cleaved Fu@pep-CLipo was developed for highly efficient and precise thrombolysis...

Webinar: Multimodal Assessment of Hypoxia in Tumors: From the Lab to the Clinic

Bruker Biospin

Apr 2, 2024

25 April 2024, 4PM CET
This webinar will be of interest to multiple profiles in the community of biomedical
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Apr 20, 2024

Multiplexed tissue imaging using the Orion platform to reveal the Spatial Biology of Cancer

RareCyte

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In this webinar Prof. Sandro Santagata, will reveal how Orion high-plex imaging and the use of this data, is valuable...

A 19-color single-tube Full Spectrum Flow Cytometry for the detection of Acute Myeloid Leukemia

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This recent publication in Cytometry Part A describes the development and comprehensive workflow of a single-tube,...

18F-labeled somatostatin analogs for somatostatin receptors (SSTRs) targeted PET imaging of NETs

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A novel 18F-radiolabeled somatostatin analogue, [Al18F]NODA-MPAA-HTA, was synthesized and evaluated for positron...

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Discover Yokogawa CellVoyager CQ1: Benchtop High-Content Analysis System

Yokogawa

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Unlike flow cytometers, the CellVoyager CQ1 confocal quantitative image cytometer does not require pretreatment such as...

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Webinar recording: BioFlux, the gold standard for Platelet Biology and Vascular Pharmacology studies

Jan 3, 2024

After a short introduction on the physio-pathological roles of platelets and the importance of their cell adhesion mechanisms for human health, I will present data from our most recent studies on the redox-dependent regulation of platelet activity and the role of NADPH oxidases (NOXs) in thrombosis using the BioFlux system. We discovered agonist specificity of the activation of NADPH oxidases during platelet activation, with NOX1 prominently activated by collagen, while thrombin and other agonists activate both NOX1 and NOX2. The inhibition of NOX1 has strong antiplatelet effects in vitro.

Collagen-dependent thrombus formation under flow is abolished by NOX1 inhibition in human platelets or genetic deletion in mouse platelets. Importantly, although thrombosis tested in vivo in carotid occlusion and pulmonary embolism assays is severely impaired by NOX1 inhibition, haemostasis remains unaffected. This suggests the possibility to design NOX1-specific drugs to be used as antithrombotics with no bleeding side effects. This work suggests how the modelling of thrombus formation by flow assays in vitro may find important applications in vascular biology and drug discovery.

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Riccardo Pasculli

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Fluxion Biosciences

With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.

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