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Low-dose imaging in preclinical total-body PET/CT scanner

Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. New preclinical PET/CT system is presented with design features which make it suitable for small animal low-dose imaging

Apr 8, 2020

Scientific paper
Application

Loss of Notch1 activity inhibits prostate cancer growth

 Prostate cancer remains among the leading causes of cancer-related deaths in men. Loss of NOTCH1 in aggressive prostate cancer cells decreases proliferation, invasion, and tumorsphere formation.

Apr 1, 2020

Scientific paper
Application

Accelerate your biomedical research

"The Cabinet Biological Irradiator X-RAD 225XL is used in our Institute very frequently (more than one thousand times per year) for routine x-ray irradiation of mice and cultivated cells."

Assoc. Prof. Stanislav Pavelka, Ph.D.

Department of X-Ray Irradiation, Institute of Molecular Genetics of the CAS, Prague, Czech Republic

Internal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice

MicroPET-based dosimetry of 152Tb is feasible, and the comparison with organ harvesting resulted in acceptable dose discrepancies for body districts that can be segmented on CT. 

Feb 20, 2020

Scientific paper
Application

Genotype-targeted local therapy of glioma

Lower-grade gliomas are often characterized by mutations in metabolism-related genes isocitrate dehydrogenase 1 (IDH1) and IDH2. Resection of these tumors is constrained by adjacent eloquent cortex, resulting in local failures. 

Mar 26, 2020

Scientific paper
Application

Webinar recording: Ex vivo microangioCT, advances in microvascular imaging

A new technique called microangioCT imaging is being used with a novel polymerizing contrast agent that enables 3D visualization of organ vasculature at unprecedented levels.

Mar 16, 2020

Application
Webinar

Accelerate your biomedical research

"Thanks to the Vevo 2100, high-frequency ultrasound, we are able to evaluate multiple animal models of human cardiovascular diseases and tumoral pathology. It is an excellent tool for applying basic research to disease translational research".

Dr. Bogdan Marinescu

'Victor Babeș' National Institute of Pathology, Bucharest, Romania

Cancer cells resist mechanical destruction in the circulation via RhoA-myosin II axis

Tumors may generate millions of Circulating tumor cells per day, but seminal work in cancer biology has established the concept of metastatic inefficiency whereby only a small fraction of these CTCs go on to generate clinically observable metastases.

Mar 20, 2020

Scientific paper
Application

Comparing image quality in Phase Contrast X-Ray Tomography

How to evaluate and compare image quality from different submicrometer CT scans? A simple yet clever test phantom is used for recording 13 scans in a number of commercial and some non-commercial scanners

Feb 28, 2020

Scientific paper
Application

AutoLV analysis software

AutoLV analysis software is the latest addition to VisualSonics robust suite of measurement tools customized for preclinical small animal research. 

Feb 11, 2020

Scientific paper
Application
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