Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence, fluorescence and X-Ray for in vivo imaging analysis.

This work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in LUSC, and suggests that NSD3-dependency renders LUSC therapeutically vulnerable to bromodomain inhibition.

Intravital microscopy can visualize various in vivo cellular-level dynamics such as cell trafficking, cell-to-cell or cell-to-microenvironment interactions in a living animal. Intravital imaging of pathophysiological cellular dynamics in natural in vivo microenvironment in various preclinical animal model can provide an unprecedented insight in the dynamic processes of human diseases beyond conventional histological observation of ex vivo sample or in vitro culture sample.

Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease. Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological cascade after TBI.

Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma. BEZ235 is an effective dual PI3K/mTOR inhibitor, but it was withdrawn from early-phase clinical trials owing to poor solubility and on-target/off-tumor toxicity.

Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively. However, it cannot reveal a detailed depth-dependent distribution profile of transdermally delivered agents in the skin.

We look forward to welcoming many of our users to 2021 PMOD User Meeting. The theme of our PMOD User Meeting will be “Tips & tricks for tracer evaluation and longitudinal studies.”