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Spectral Instruments Imaging webinar : The roles of preclinical optical imaging in cancer research

Highlighting bioluminescent imaging in Oncology applications with Dr. Michael Henry, Professor of department of Molecular Physiology & Biophysics, University of Iowa Carver College of Medicine.

Jul 27, 2021

High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma

Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence, fluorescence and X-Ray for in vivo imaging analysis.

Jul 21, 2021

Scientific paper
Application

Accelerate your biomedical research

"In our lab, we use microCT Skyscan 1276 for visualization of vasculature and cancer in mice model. Xtreme II is powerful tool for molecular imaging. In our research group, Xtreme II is commonly used to assess the biodistribution of novel drug candidates in small animal model."

Adam Novobilský, Ph.D.

Dept. Pharmacology and Immunotherapy, Veterinary Research Institute, Brno, Czech Republic

Elevated NSD3 histone methylation activity drives squamous cell lung cancer

This work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in LUSC, and suggests that NSD3-dependency renders LUSC therapeutically vulnerable to bromodomain inhibition.

Jun 8, 2021

Scientific paper
Application

ACCELA webinar recording : IntraVital Microscopy (IVM): In Vivo Live Cell Imaging Platform

Intravital microscopy can visualize various in vivo cellular-level dynamics such as cell trafficking, cell-to-cell or cell-to-microenvironment interactions in a living animal. Intravital imaging of pathophysiological cellular dynamics in natural in vivo microenvironment in various preclinical animal model can provide an unprecedented insight in the dynamic processes of human diseases beyond conventional histological observation of ex vivo sample or in vitro culture sample.

Jul 13, 2021

Application
Webinar

Microvascular injury in mild traumatic brain injury accelerates alzheimer-like pathogenesis in mice

Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease. Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological cascade after TBI.

Jun 22, 2021

Application
Product news

Accelerate your biomedical research

"The Cellvizio Dual Band is capable of achieving cell to sub-cell resolution in vivo, from surface to deep tissues. The system allow us to monitor multiple dynamic processes, physiological pathways or cellular interactions in vivo in the same animal over longitudinal studies."

Assoc.Prof. M.D. Jakub Otáhal

Czech Academy of Sciences, Institute of Physiology, Prague, Czech Republic

Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles

Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma. BEZ235 is an effective dual PI3K/mTOR inhibitor, but it was withdrawn from early-phase clinical trials owing to poor solubility and on-target/off-tumor toxicity.

Jun 23, 2021

Scientific paper
Application

Quantitative two-photon microscopy imaging analysis of human skin

Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively. However, it cannot reveal a detailed depth-dependent distribution profile of transdermally delivered agents in the skin.

Jun 21, 2021

Scientific paper
Product news

PMOD Virtual User Meeting

We look forward to welcoming many of our users to 2021 PMOD User Meeting. The theme of our PMOD User Meeting will be “Tips & tricks for tracer evaluation and longitudinal studies.”

Jun 7, 2021

Technical breakthrough
Webinar

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