Treatment resistance is associated with tumor cells molecular plasticity. In metastatic castration resistant prostate cancer (mCRPC), alterations in androgen receptor (AR) have been described as predictors of shorter response to hormonal treatments.

13C-Hyperpolarized molecules provide a unique signature for molecular processes relevant to a range of disease processes that can be imaged by MRI and promises improved detections for certain indications relative to traditional molecular imaging

Extracellular  vesicles  (EVs)  are  prevalent  in biological  fluids  and  are  of  great  interest  to researchers  due  to  the  compelling  evidence for their vital roles in cell signalling,  immune response   modulation and apoptosis.

Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models is of great importance in preclinical metabolic research. In MRI, fat suppression is often performed to avoid artifacts arising from fat.

The steady progress made over the past threedecades in growing a variety of inorganic nanomaterials, with discreet control over their size and photophysical properties,has been exploited to develop several imaging and sensing applications.

To develop and validate immuno-oncology therapies, scientists must understand the full dynamics of cytotoxic effectors in action as well as the destruction of target tumors.

Pancreatic ductal adenocarcinoma has been increasing by 0.5% per year in the United States. This study describes the generation and characterization of a novel oncolytic chimeric orthopoxvirus for the treatment of pancreatic cancer.