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Tycho - NanoTemper

Quickly detect the quality of any protein using a tiny volume of sample

Finding out the quality of your protein up front helps to figure out if it’s functional, similar to the previous batch, or properly stored. With very little effort, you make sure you’re moving forward with a viable sample, and save yourself from doing have-to-repeat-it-again experiments.

Tycho verifies protein quality by looking at the structural integrity (or foldedness) of a protein. As a thermal ramp is applied, the changes in the intrinsic fluorescence, detected at both 350 nm and 330 nm, from tryptophan and tyrosine residues in the protein are measured. These changes in fluorescence signal indicate transitions in the folding state of a protein. The temperature at which a transition occurs is called the inflection temperature (Ti). The fluorescence is recorded during the thermal run, plotted as ratio and used to calculate Ti. It’s initial value along with the change in signal over the run (Δ ratio) is also recorded.

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https://nanotempertech.com/tycho/
Igor Valerián

Business director

Igor

Valerián

+420 603 223 602

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