Accelerate to discover

Back to filter

Related topics

Bruker webinar: Ear evolution in fossil mammals

Bruker Biospin

Nov 27, 2020

Hearing is just one of the functions aside of providing balance. Even juveniles obtain a fully developed ear region...

ONI Nanoimager joins the fight against COVID-19

ONI

Nov 24, 2020

ONI is supporting the global effort into research and diagnostics to tackle the COVID-19 pandemic. ONI is currently...

Early immune response in mice immunized with inactivated vaccine against SARS-CoV-2

Cytek Biosciences

Nov 19, 2020

The development of a vaccine against COVID-19 is a hot topic for many research laboratories all over the world. Our aim...

Bruker announces software provider PMOD Technologies LLC

Bruker Biospin

Nov 13, 2020

PMOD Technologies aims to equip researchers with best-in-class software tools for biomedical imaging research in humans...

Nov 29, 2020

Microvascular injury in mild traumatic brain injury accelerates alzheimer-like pathogenesis in mice

RWD

Nov 9, 2020

Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD)....

Discover the new NovoCyte Penteon - when exceptional performance meets simplicity

Agilent technologies

Nov 6, 2020

The NovoCyte Penteon flow cytometer builds on its successful predecessor, the NovoCyte. You now have the flexibility to...

CS-FNX Hitachi Koki, discover the state-of-art ultracentrifuges series

Hitachi Koki

Nov 4, 2020

Hitachi Koki, as a world leading producer of centrifuges offers general purpose floor standing and table top...

Nov 29, 2020

Curiox webinar - how to retain more cells for Single Cell Sequencing and proteogenomics ?

Curiox

Oct 28, 2020

Do you think that centrifuging cells at 500 x g is not going to cause issues? Moreover, sample prep involving...

Show all topics (10)

Amphiphilic nanocarrier leads to improved therapeutic response in pancreatic cancer

Mar 29, 2018

The heterogeneity of pancreatic ductal adenocarcinoma (PDAC) suggests that successful treatment might rely on simultaneous targeting of multiple genes, which can be achieved by RNA interference-based therapeutic strategies. Hadas Gibori (Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University) and his team show here a potent combination of microRNA and siRNA delivered by an efficient nanocarrier to PDAC tumors.

Using proteomic-microRNA profiles and survival data of PDAC patients from TCGA, they found a novel signature for prolonged survival. Accordingly, they used a microRNA-mimic to increase miR-34a together with siRNA to silence PLK1 oncogene. For in vivo dual-targeting of this combination, they developed a biodegradable amphiphilic polyglutamate amine polymeric nanocarrier (APA). APA-miRNA–siRNA polyplexes systemically administered to orthotopically inoculated PDAC-bearing mice showed no toxicity and accumulated at the tumor, resulting in an enhanced antitumor effect due to inhibition of MYC oncogene, a common target of both miR-34a and PLK1. Taken together, their findings warrant this unique combined polyplex’s potential as a novel nanotherapeutic for PDAC.

Read more

Scientific paper
Application

Related technologies: Probe based confocal microscopy

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 255 700 886

Send Message

Brand profile

Mauna Kea Technologies

Mauna Kea Technologies manufactures Cellvizio Lab, confocal probe based imaging system, providing cellular-level images with minimal invasiveness for longitudinal studies.

Related products

Cellvizio Lab is a single band fiber based microscope for observing in real time at cellular scale

show detail

Cellvizio, a fiber based microscope for observing in real time at cellular scale, features simultaneous, co-registered dual band excitation and detection

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey