BioNano Genomics, the leader in physical genome mapping, announced updates regarding expansions of its product offerings and capabilities. To exploit this new IrysView mapping software feature, researchers need to select different enzymes to barcode, or tag, the genome at specific locations. The availability of the new enzyme Nb.BssSI by New England Biolabs, Inc., expands the number of genomes that can be integrated by NGM and complements the existing portfolio of enzymes, thereby providing an additional, independent means to optimize the mapping and analysis of genomes. For analysis of human genomes, BioNano currently recommends use of NEB’s Nt.BspQI to nick DNA prior to labeling. The addition of Nb.BssSI enables the labeling of DNA at a second specific site within a genome, providing greater scaffold contiguity, completeness and correctness.