Accelerate to discover

Back to filter

Related topics

Cell plasticity associated to circulating tumor cells from prostate cancer patients

Fluxion Biosciences

Mar 13, 2019

Treatment resistance is associated with tumor cells molecular plasticity. In metastatic castration resistant prostate...

Izon qEV - The fastest & most effective Exosome isolation

IZON

Mar 6, 2019

Extracellular  vesicles  (EVs)  are  prevalent  in biological  fluids  and  are  of  great  interest  to researchers ...

Enhanced uptake of luminescent quantum dots by live cells

Etaluma

Mar 1, 2019

The steady progress made over the past threedecades in growing a variety of inorganic nanomaterials, with discreet...

Fat-water separation Imaging in Preclinical MRI

Bruker Biospin

Mar 1, 2019

Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models is of great importance in...

Mar 20, 2019

New technique for dynamic monitoring of liquid tumor Cytotoxicity

Acea Biosciences

Feb 12, 2019

To develop and validate immuno-oncology therapies, scientists must understand the full dynamics of cytotoxic effectors...

Small animal 13C-hyperpolarized MRI

Bruker Biospin

Feb 8, 2019

13C-Hyperpolarized molecules provide a unique signature for molecular processes relevant to a range of disease...

Oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts

Spectral Instruments Imaging

Jan 30, 2019

Pancreatic ductal adenocarcinoma has been increasing by 0.5% per year in the United States. This study describes the...

Mar 20, 2019

Responsive fluorescence probe for detection of Hypochlorous acid in live cells and animals

Spectral Instruments Imaging

Jan 17, 2019

In this work, a new fluorescence probe, PQI, was developed for monitoring of the HOCl level in biological samples. The...

Show all topics (10)

Genome-wide structural variation detection by genome mapping on nanochannel arrays

Jun 14, 2016

„Comprehensive whole genome structural variation detection is challenging with current approaches. With diploid cells as DNA source and the presence of numerous repetitive elements, short read DNA sequencing cannot be used to detect structural variation efficiently. In this report, we show that genome mapping with long, fluorescently labeled DNA molecules imaged on nanochannel arrays can be used for whole genome structural variation detection without sequencing. While whole genome haplotyping is not achieved, local phasing (across >150 kb regions) is routine, as molecules from the parental chromosomes are examined separately. In one experiment, we generated genome maps from a trio from the 1000 Genomes Project, compared the maps against that derived from the reference human genome, and identified structural variation that are >5 kb in size. We find that these individuals have many more structural variants than those published, including some with the potential of disrupting gene function or regulation.“ Mak et al. (2015): Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays. In Genetics. 2015

Read more

Scientific paper
Application

Related technologies: Genome mapping

Brand profile

BioNano Genomics

A revolutionary NanoChannel technology for Genome mapping of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias.

Related products

Genome maps of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey