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Theranostics: From Mice to Men and Back
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Recorded webinar
Presenters: Prof. Dr. Ken Herrmann and Prof. Dr. Katharina Lückerath – Moderator: Hannah Notebaert
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Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation...
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MRI images were obtained using the 9.4T Bruker BioSpec system, equipped with 40 mm 1H quadrature volume resonator, and...
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The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...
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April 2024 publication revealing benefits of using intravital microscopy in trascriptomics studies
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Minimal information for studies of extracellular vesicles (MISEV2023)
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Omics Studies of Tumor Cells under Microgravity Conditions
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It is important for the analysis of data from space experiments to distinguish unspecific stress reactions from...
Jun 14, 2017
3D organotypic culture models such as organoids and multicellular tumor spheroids (MCTS) are becoming more widely used for drug discovery and toxicology screening. As a result, 3D culture technologies adapted for high-throughput screening formats are prevalent. While a multitude of assays have been reported and validated for high-throughput imaging (HTI) and high-content screening (HCS) for novel drug discovery and toxicology, limited HTI/HCS with large compound libraries have been reported. Nonetheless, 3D HTI instrumentation technology is advancing and this technology is now on the verge of allowing for 3D HCS of thousands of samples. This review focuses on the state-of-the-art high-throughput imaging systems, including hardware and software, and recent literature examples of 3D organotypic culture models employing this technology for drug discovery and toxicology screening.
Related technologies: Live cell imaging | Automated microscopy and Spatial Proteomics
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Essen BioScience & Sartorius is a team of engineers and biologists with deep expertise in cell-based assays and biomolecular interaction analysis. They invent, manufacture, supply and support instrumentation, reagents and protocols.
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essenbioscience.com/en/
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