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High-throughput observation of molecular motor activity & dynamics

Feb 21, 2018

The cytoskeleton and its many molecular motors are major players in a variety of cellular functions. The interconnected networks of cytoskeletal filaments act as tracks directing molecular motor transport and provide structural support and organization to cells. With optical tweezers, we are capable of resolving sub-nanometer displacements and applying pico-Newton forces on single proteins. This force spectroscopy approach has proven extremely useful in elucidating the mechanics and kinetics of molecular motors involved in intracellular transport. 

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Related technologies: Label-free protein analysis

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Regina Fillerová

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LUMICKS

Optical tweezers, Confocal microscopy, STED nanoscopy, Acoustic force spectroscopy for single-molecule biophysics. 

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Live, simultaneous and correlative visualization and manipulation of molecular interactions with sub-picoNewton force resolution and sub-nm position resolution.

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The first dedicated optical tweezers instrument specifically developed for high-resolution single-molecule force spectroscopy research.

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Acoustic Force Spectroscopy is a single-molecule, lab-on-a-chip technology in which acoustic waves are used to exert forces on thousands of biomolecules.

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