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New technologies to uncover the molecular basis of disorders of sex development

BioNano Genomics

Aug 16, 2018

Newer approaches, such as whole-genome sequencing and whole-genome mapping have the potential to identify novel...

Functional Imaging

Bruker Biospin

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Acea Biosciences

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Great ape genomes laid bare

BioNano Genomics

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Aug 18, 2018

Dynamic PET imaging and special focus in cardiac kinetic analysis

Bruker Biospin

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Micro-computed tomography, or micro-CT, is being employed by a rapidly increasing number of laboratories for bone...

Novel insights on the mechanical properties of IFs using LUMICKS’ technology

LUMICKS

Jul 30, 2018

The journal Science Advances has recently published the paper ‘Viscoelastic properties of vimentin originate from...

Image filtering and Image enhancement

Bruker Biospin

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This issue of Bruker MicroCT Academy is focused on image filtering and enhancement of the picture. Having problems with...

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Intact DNA purified from flow-sorted nuclei unlocks the potential of next-generation genome mapping

Sage Science

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Pulsed-field gel electrophoresis from Sage Science was used for a project to improve sample prep protocols for...

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HistoQuest software in cancer research

Mar 22, 2016

Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of Stat3 or IL-6 signalling in a Pten-deficient PCa mouse model accelerates cancer progression leading to metastasis. Mechanistically, we identify p19ARF as a direct Stat3 target. Loss of Stat3 signalling disrupts the ARF–Mdm2–p53 tumour suppressor axis bypassing senescence. Strikingly, we also identify STAT3 and CDKN2A mutations in primary human PCa. STAT3 and CDKN2A deletions co-occurred with high frequency in PCa metastases. In accordance, loss of STAT3 and p14ARF expression in patient tumours correlates with increased risk of disease recurrence and metastatic PCa. Thus, STAT3 and ARF may be prognostic markers to stratify high from low risk PCa patients. Our findings challenge the current discussion on therapeutic benefit or risk of IL-6/STAT3 inhibition.

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TissueGnostics

TissueGnostics develops systems for automated identification and functional characterization of single cells in tissue sections, cultured and smeared cells as well as TMA. This includes automated image acquisition and image processing for immunohistochemistry, multi-chanel immunofluorescence and hematology.

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HistoFAXS is a cutting-edge tool for cell-based staining intensity analysis of immunohistochemical routine samples and research experiments

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