Accelerate to discover

Back to filter

Related topics

Visualization of Tumor-Related Blood Vessels in Small Animals by Photoacoustic 3D Imaging System

Luxonus

Feb 21, 2024

In Vivo Label-Free Observation of Tumor-Related Blood Vessels in Small Animals Using a Newly Designed Photoacoustic 3D...

Therapeutic effects of mesenchymal stem cells in myocardial infarction

S-Sharp

Feb 19, 2024

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem...

Evaluation with BLI of synthetic immune checkpoint engagers in allogenic mice

Spectral Instruments Imaging

Jan 17, 2024

Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity

Application of focal X-ray irradiation in canaries

Precision X-Ray

Jan 15, 2024

Effects of the depletion of neural progenitors by focal X-ray irradiation on song production and perception in canaries

Mar 2, 2024

Radiation planning for image guided preclinical radiotherapy

Precision X-Ray

Jan 12, 2024

Doctoral Thesis, Stefan van Hoof, Maastricht University 2019

IVM and single cell transcriptomic analysis for engraftment of mesenchymal stem cells

IVIM Technology

Jan 10, 2024

To facilitate the translation of preclinical studies into clinical practice, the precise in vivo behaviors of the...

Small animal DXA instrument comparison and validation 2024

MEDIKORS

Jan 8, 2024

This study evaluated the performance of two relatively new peripheral bone densitometry machines, the InAlyzer and the...

Mar 2, 2024

Explore the new Agilent Cell Therapy virtual lab

Agilent technologies

Jan 2, 2024

As the Cell and Gene therapy space expands rapidly, highly sophisticated technologies and instrumentation are required...

Show all topics (10)

HistoQuest software in cancer research

Mar 22, 2016

Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of Stat3 or IL-6 signalling in a Pten-deficient PCa mouse model accelerates cancer progression leading to metastasis. Mechanistically, we identify p19ARF as a direct Stat3 target. Loss of Stat3 signalling disrupts the ARF–Mdm2–p53 tumour suppressor axis bypassing senescence. Strikingly, we also identify STAT3 and CDKN2A mutations in primary human PCa. STAT3 and CDKN2A deletions co-occurred with high frequency in PCa metastases. In accordance, loss of STAT3 and p14ARF expression in patient tumours correlates with increased risk of disease recurrence and metastatic PCa. Thus, STAT3 and ARF may be prognostic markers to stratify high from low risk PCa patients. Our findings challenge the current discussion on therapeutic benefit or risk of IL-6/STAT3 inhibition.

Read more

Scientific paper

Brand profile

TissueGnostics

TissueGnostics develops systems for automated identification and functional characterization of single cells in tissue sections, cultured and smeared cells as well as TMA. This includes automated image acquisition and image processing for immunohistochemistry and multi-chanel immunofluorescence.

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey