Accelerate to discover

Back to filter

Related topics

Early immune response in mice immunized with inactivated vaccine against SARS-CoV-2

Cytek Biosciences

Nov 19, 2020

The development of a vaccine against COVID-19 is a hot topic for many research laboratories all over the world. Our aim...

Bruker announces software provider PMOD Technologies LLC

Bruker Biospin

Nov 13, 2020

PMOD Technologies aims to equip researchers with best-in-class software tools for biomedical imaging research in humans...

Microvascular injury in mild traumatic brain injury accelerates alzheimer-like pathogenesis in mice

RWD

Nov 9, 2020

Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD)....

Live animal imaging - Humane animal research

Bruker Biospin

Oct 26, 2020

Drawing on over 50 years of expertise in the life and animal sciences, Bruker designs preclinical imaging systems that...

Nov 24, 2020

Meet the Expert - Brent Barre interview

emka TECHNOLOGIES

Oct 21, 2020

Learn what a researcher at the forefront of COVID-19 research has to say about his current research environment.

Automated fever & hypothermia detection

emka TECHNOLOGIES

Oct 14, 2020

As one of the oldest clinical indicators of disease in mammals, temperature is a crucial parameter to monitor,...

Multi-modal molecular imaging driving pre-clinical research & pharmaceutical development

Bruker Biospin

Oct 6, 2020

Multi-modal molecular imaging at Massachusetts General Hospital – driving pre-clinical research and patient pathways...

Nov 24, 2020

Imaging Performance of a multimodal module to enhance preclinical irradiator capabilities

Precision X-Ray

Sep 15, 2020

Upgrading an existing irradiator with such a multi-modal imaging device is a reasonable investment in laboratories...

Show all topics (10)

Hypoxia activates constitutive Luciferase reporter constructs

Jul 13, 2017

Studies in our laboratory sought to examine the hypoxic regulation of HIF activity in placental trophoblast cells, through the use of dual-reporter luciferase assays. Our study demonstrates that hypoxic conditions cause a significant increase in the level of constitutive luciferase reporter activity. We also show that this induction is not a cell-type or species-specific phenomenon and provides an alternative method for normalizing transfection efficiency in luciferase assays under hypoxic conditions. Our results suggest that in studies dealing with hypoxic conditions, caution should be used when interpreting measurements of transcriptional activity by traditional dual-reporter assays.

Read more

 

Scientific paper

Get more info

Riccardo Pasculli

Head of application support

Riccardo

Pasculli

+420 731 127 717

Send Message

Brand profile

COY laboratory products

Coy Labs produces Glove Boxes, Anaerobic Chambers, and controlled atmosphere glove boxes.

Related products

The flexible nature of the unit allows for the user to reach deeper and higher into the unit

show detail

Gloveless anaerobic chambers offer the operator a convenient glove-free ability to handle and inspect samples under low oxygen (0-5 ppm) conditions

show detail

InVitro glove boxes – incubation, culture maintenance and analysis in the same environment

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey