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New technologies to uncover the molecular basis of disorders of sex development

BioNano Genomics

Jul 13, 2018

Newer approaches, such as whole-genome sequencing and whole-genome mapping have the potential to identify novel...

δT cells and CD8+ T cells targeting of breast cancer cells

Etaluma

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Cancer stem cells (CSCs) are a large cause of metastasis in breast cancer. They are also very resistent to any...

Incucyte system used for generating single-cell-derived cancer-associated fibroblast clones

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Use whole-well, label-free imaging to automatically scan for clones and verify monoclonality. Integrated image...

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First DLS paper: Sorghum genome assembled with nanopore sequencing and DLS

BJS Biotechnologies

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The new paper describes a chromosome-scale de novo assembly of the repeat-rich Sorghum bicolor Tx430 genome built using...

Real-time study of platelet formation under sheer-flow with Lumascope

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Early fetal sex determination using micro-volume of maternal plasma

BJS Biotechnologies

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 A qPCR-based assay, SneakPeek Early Gender Test (Gateway Genomics) has been developed to determine fetal sex as early...

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3R Compliant drug development studies

Bruker Biospin

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In preclinical imaging, magnetic resonance imaging (MRI) can be an attractive alternative to researchers who have...

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Looking for structural variations with IRYS from BioNano Genomics

Mar 15, 2016

Despite recent advances in base-calling accuracy and read length, de novo genome assembly and structural variant analysis using ‘short read’ shotgun sequencing remain challenging. Most resequencing projects rely on mapping the sequencing data to the reference sequence to identify variants of interest. Whole-genome scanning techniques have revealed the prevalence and importance of structural variation. Detecting copy number variation often relies on detection of relative signal intensities by array-based or quantitative PCR-based technologies. However, except for deletions, these methods do not provide positional information regarding the locations of copy number variants, and they cannot detect balanced structural variation, such as inversions or translocations.. The instrumentation presented by BioNano Genomics can improve de novo sequence assembly by providing long labeled DNA contigs with so far unknown structural variations.

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Application

Related technologies: Genome Mapping

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BioNano Genomics

A revolutionary NanoChannel technology for Genome mapping of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias.

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Genome maps of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias

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