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Low-dose maging in a new preclinical total-body PET/CT scanner

Aug 28, 2019

CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose range have been previously described. [18F]FDG body doses in mice have been estimated to be in the range of 100 mGy for [18F]FDG. Yearly, the average whole body doses due to handling of activity by PET technologists are reported to be 3–8 mSv.
The CT subsystem of new PET/CT uses a X-source power that is optimized for small animal imaging. The system design incorporates a spatial beam shaper coupled with a highly sensitive flat-panel detector and very fast acquisition (Now the total-body mouse PET/CT studies could be completed with total doses of

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