Accelerate to discover

Back to filter

Related topics

Synthesis and characterization of functional nanofilm-coated live Immune cells using CQ1

Yokogawa

Apr 10, 2019

Layer-by-layer assembly techniques have been extensively studied in cell biology because of their simplicity of...

Product update: The high pass plus cassette

Sage Science

Apr 9, 2019

The high pass plus gel cassette is the newest addition to the Pippin family. It is dedicated to the BluePippin...

Novel imaging-based assay for hERG channel inhibition using iPS-derived Cardiomyocytes

Yokogawa

Apr 4, 2019

A large percentage of drugs fail in clinical studies due to cardiac toxicity, such as drug-induced QT...

Modified Beta-carotene-bound albumin nanoparticles for breast tumor ablation

Spectral Instruments Imaging

Mar 29, 2019

The albumin nanoparticles were fabricated using a beta-carotene cross-linker via the Nab technique. These new albumin...

Apr 20, 2019

Spectral flow cytometric analysis of loss-of-function mutations in granular cell tumors

Cytek Biosciences

Mar 29, 2019

Granular cell tumors (GCTs) are rare tumors that can arise in multiple anatomical locations,and are characterized by...

IncuCyte white paper: live-cell analysis for Neuroscientists

Sartorius

Mar 20, 2019

Stem cell technologies using iPSCs allow researchers to create differentiated neurons and support cells to study human...

Cell plasticity associated to circulating tumor cells from prostate cancer patients

Fluxion Biosciences

Mar 13, 2019

Treatment resistance is associated with tumor cells molecular plasticity. In metastatic castration resistant prostate...

Apr 20, 2019

Izon qEV - The fastest & most effective Exosome isolation

IZON

Mar 6, 2019

Extracellular  vesicles  (EVs)  are  prevalent  in biological  fluids  and  are  of  great  interest  to researchers ...

Show all topics (10)

Method to quantify local force distribution within biomolecular systems

May 24, 2018

By using optical tweezers coupled with fluorescence microscopy, Dr. King et al. (2018) studied the ability of cyanine intercalator dyes to quantify the molecular tension within biomolecular structures. They found that intercalators can be used in biomolecular systems in real-time to measure the tension locally and to determine how applied forces are partitioned. As an example, the authors demonstrated that stretched and entwined DNA structures can generate transient DNA-DNA interactions that mimic DNA bridges, by measuring the tension and local force distribution within the structures.

Scientific paper
Technical breakthrough
Product news

Related technologies: Single-molecule Interactions

Get more info

Regina Fillerová

Field application specialist

Regina

Fillerová

+420 731 127 718

Send Message

Brand profile

LUMICKS

Optical tweezers, Confocal microscopy, STED nanoscopy, Acoustic force spectroscopy for single-molecule biophysics. 

Related products

Live, simultaneous and correlative visualization and manipulation of molecular interactions with sub-picoNewton force resolution and sub-nm position resolution.

show detail

The first dedicated optical tweezers instrument specifically developed for high-resolution single-molecule force spectroscopy research.

show detail

Acoustic Force Spectroscopy is a single-molecule, lab-on-a-chip technology in which acoustic waves are used to exert forces on thousands of biomolecules.

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey