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The clinical use of full-length mAbs as imaging agents can be challenging, due to their long biological half-life and relatively slow tumor penetration, which may affect tumor-to-background contrast at early time points. To circumvent these issues, Dr Gabriela Kramer-Marek’s team has developed radiolabeled affibody-based PET tracers that still have high specificity and affinity of the potential therapeutic mAb, but their molecular weight below 60 kDa allows for rapid renal clearance and elimination. In this webinar, Dr Gabriela Kramer-Marek will focus on HER-specific imaging radioconjugates that could provide unique information as cancer biomarkers, including quantification of receptor heterogeneity and early detection of changes in target expression in response to therapy.
Dr Ali Asgar Attarwala, Bruker BioSpin and Dr Gabriela Kramer-Marek, Team Leader Preclinical Molecular Imaging, The Institute of Cancer Research London
Related technologies: PET, SPECT, CT
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Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.
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www.bruker.com
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