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RainDrop Digital PCR system provides lower limit of detection down to 1 > 1 million

Mar 22, 2016

For many assays, dPCR sensitivity is significantly higher than traditional PCR analysis, and the accuracy and precision of the assay improves by counting larger numbers of molecules individually. The sensitivity of digital PCR will facilitate detection limits that redefine our understanding of disease onset, progression, and recurrence. One particularly attractive application of digital PCR is the quantitative detection of a small number of mutated DNA molecules among a large number of wild-type molecules, which is relevant to cancer research, and especially for the detection of minor alleles. Cancerous tissue is often highly heterogeneous and cancer biomarkers vary across types of disease and stages of disease progression which complicates cancer detection and identification at early stages. The RainDrop dPCR System within its droplets productivity offers outstanding performance regarding lower limit of detection. 

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Scientific paper

Related technologies: Digital PCR

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RainDance Technologies

RainDance company’s ultra-sensitive genomic tools enable research of novel non-invasive liquid biopsy applications that should result in more accurate, reliable, cost-effective, and early detection of cancer and other inherited and infectious diseases.

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Capable of generating more than a billion reactions in a single day, the RainDrop system surpasses all existing technologies and establishes a new performance standard in sensitivity, quantitation and multiplexing.

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