Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
Automated microscopy and Spatial Proteomics
Real-time, label free cell analysis
Nano and micro particle analysis
Accelerate to discover
Related topics
A 19-color single-tube Full Spectrum Flow Cytometry for the detection of Acute Myeloid Leukemia
Mar 13, 2024
This recent publication in Cytometry Part A describes the development and comprehensive workflow of a single-tube,...
18F-labeled somatostatin analogs for somatostatin receptors (SSTRs) targeted PET imaging of NETs
Mar 11, 2024
A novel 18F-radiolabeled somatostatin analogue, [Al18F]NODA-MPAA-HTA, was synthesized and evaluated for positron...
Discover Yokogawa CellVoyager CQ1: Benchtop High-Content Analysis System
Mar 8, 2024
Unlike flow cytometers, the CellVoyager CQ1 confocal quantitative image cytometer does not require pretreatment such as...
Real-time and quantitative analysis of Macrophage Phagocytosis with RTCA eSight
Feb 23, 2024
The eSight is currently the only instrument that interrogates cell health and behavior using cellular
impedance...
Visualization of Tumor-Related Blood Vessels in Small Animals by Photoacoustic 3D Imaging System
Feb 21, 2024
In Vivo Label-Free Observation of Tumor-Related Blood Vessels in Small Animals Using a Newly Designed Photoacoustic 3D...
Therapeutic effects of mesenchymal stem cells in myocardial infarction
Feb 19, 2024
Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem...
Whole-slide biomarker quantitation in 82-patient NSCLC cohort study of acquired resistance to PD-(L)
Feb 7, 2024
Samples from 82 patients with NSCLC and matched pre- and post-ICI biopsies were subjected to genomic profiling and to...
Evaluation with BLI of synthetic immune checkpoint engagers in allogenic mice
Jan 17, 2024
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity
Jun 6, 2018
Use of kinase inhibitors (KI) for therapeutic purposes is limited by their cardiotoxicity. Therefore, further design of new KIs further understanding is required. In the human genome there are over 500 kinases present. The binding site for ATP is quite conserved between them creating polypharmacology. Because kinases show flexibility in binding across the kinome, researchers in this study have assesed the effects on cardomyocyte beating. After this high throuhput analysis 30 of the inicial 65 kinases were deemed to have met the criteria of having pharmacological inhibition, expression in both human induced pluripotent stem cell-derived cardiomyocytes and adult heart tissue, and effect on cardomyocyte beating following single gene knockdown. These kinases were then chosen for a mechanistic study.
The xCELLigence system was used to predict cytotoxicity hazards in the study. To quote:
"Impedance-based assays with hiPSC CM have proven highly predictive for each of the leading functional cardiotoxicity hazards including arrhythmia (hERG and non-hERG related), chronotropy, inotropy, and KI induced functional cardiotoxicity"
Related technologies: Real-time, label free cell analysis
Brand profile
Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
More info at:
www.aceabio.com