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Theranostics: From Mice to Men and Back

MOLECUBES

Jun 25, 2024

Recorded webinar
Presenters: Prof. Dr. Ken Herrmann and Prof. Dr. Katharina Lückerath – Moderator: Hannah Notebaert

Orion 2024 AACR poster: 17-plex single-step stain and imaging of cell Lung Carcinoma

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RareCyte Orion is a benchtop, high resolution, whole slide multimodal imaging instrument. A combination of quantitative...

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Thursday, 11 July 2024, 16:00 CET | 10:00 EST
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Bruker Biospin

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MRI images were obtained using the 9.4T Bruker BioSpec system, equipped with 40 mm 1H quadrature volume resonator, and...

Exosome-Mediated Delivery of Small Molecules, RNA & DNA for Development of Novel Cancer Therapeutics

Spectral Instruments Imaging

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Disha Moholkar of University of Louisville's Gupta Lab
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Emulate in vivo conditions – introduce shear flow to your experiments with BioFlux system

Cell Microsystems

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Most research is still conducted in vitro without the presence of flow. We use the BioFlux System to give you the...

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High-frequency Ultrasound System For Preclinical Imaging

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May 13, 2024

The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...

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Kinase study of cytotoxicity voted paper of the year.

Jun 6, 2018

Use of kinase inhibitors (KI) for therapeutic purposes is limited by their cardiotoxicity. Therefore, further design of new KIs further understanding is required. In the human genome there are over 500 kinases present. The binding site for ATP is quite conserved between them creating polypharmacology. Because kinases show flexibility in binding across the kinome, researchers in this study have assesed the effects on cardomyocyte beating. After this high throuhput analysis 30 of the inicial 65 kinases were deemed to have met the criteria of having pharmacological inhibition, expression in both human induced pluripotent stem cell-derived cardiomyocytes and adult heart tissue, and effect on cardomyocyte beating following single gene knockdown. These kinases were then chosen for a mechanistic study.
The xCELLigence system was used to predict cytotoxicity hazards in the study. To quote:

"Impedance-based assays with hiPSC CM have proven highly predictive for each of the leading functional cardiotoxicity hazards including arrhythmia (hERG and non-hERG related), chronotropy, inotropy, and KI induced functional cardiotoxicity"

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Related technologies: Real-time, label free cell analysis

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Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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