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Synthesis and characterization of functional nanofilm-coated live Immune cells using CQ1

Yokogawa

Apr 10, 2019

Layer-by-layer assembly techniques have been extensively studied in cell biology because of their simplicity of...

Novel imaging-based assay for hERG channel inhibition using iPS-derived Cardiomyocytes

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Apr 24, 2019

Cell plasticity associated to circulating tumor cells from prostate cancer patients

Fluxion Biosciences

Mar 13, 2019

Treatment resistance is associated with tumor cells molecular plasticity. In metastatic castration resistant prostate...

Enhanced uptake of luminescent quantum dots by live cells

Etaluma

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The steady progress made over the past threedecades in growing a variety of inorganic nanomaterials, with discreet...

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Non-invasive in vivo phenotyping of adipose tissue deposits in small animal models is of great importance in...

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New technique for dynamic monitoring of liquid tumor Cytotoxicity

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To develop and validate immuno-oncology therapies, scientists must understand the full dynamics of cytotoxic effectors...

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Single-cell twitching chemotaxis in developing biofilms

Jan 24, 2017

Here we use microfluidic chemical gradients and massively parallel automated tracking to study the behavior of the pathogen Pseudomonas aeruginosa during early biofilm development. We show that individual cells can efficiently move toward chemo-attractants using pili-based “twitching” motility and the Chp chemosensory system. Moreover, we discovered the behavioral mechanism underlying this surface chemotaxis: cells reverse direction more frequently when moving away from chemoattractant sources. These corrective maneuvers are triggered rapidly, typically before a wayward cell has ventured a fraction of a micron. Our work shows that single bacteria can direct their motion with submicron precision and reveals the hidden potential for chemotaxis within bacterial biofilms.

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Scientific paper

Related technologies: Cell interaction studies

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Fluxion Biosciences

With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.

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