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Dec 28, 2020

Radio-active sources have been used routinely for the preconditioning in humanized mouse models, but safety issues have...

EV imaging series: Using ONI super-resolution to characterize single-EVs

Dec 23, 2020

To date, researchers commonly use flow-based characterization methods, fluorescence imaging techniques and electron...

Don’t Let Waste Anesthetic Gases Harm You!

Dec 21, 2020

Many projects have been devoted to the study of the correlation between anesthetics and Alzheimer’s disease....

Advances in Leukemia research using shear flow and Bioflux system

Dec 10, 2020

Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...

Dec 30, 2020

Do you have our CellRad benchtop irradiator? It’s the only one on the market!

Dec 8, 2020

The CellRad is a smaller, simpler, safer, and more cost effective alternative to radioisotope or high-powered X-ray...

Dosimetric characterization of an X-ray irradiator for use with cells

Dec 4, 2020

This study aims to characterize an X-ray irradiator for use with cells using its internal parallel-plate ionization...

Modeling multiple myeloma-Bone Marrow interactions using Synthecon rotating-wall vessels

Dec 2, 2020

Multiple myeloma develops primarily inside the bone marrow microenvironment, that confers pro-survival signals and drug...

Dec 30, 2020

Bruker webinar: Ear evolution in fossil mammals

Nov 27, 2020

Hearing is just one of the functions aside of providing balance. Even juveniles obtain a fully developed ear region...

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Target large genomic regions with 10x genomics + SageHLS

Oct 9, 2018

This approach, known as HLS-CATCH, allows users to apply long-range genomics to their gene or genomic region of interest, characterizing and phasing not only single nucleotide variants but also large structural variants including deletions, inversions, and translocations.
The HLS-CATCH+10x Genomics workflow is cost-effective. For instance, a 200Kb target can be isolated using HLS-CATCH with as few as two custom Cas9 complexes, whereas hybridization-capture methods would require hundreds to thousands of probes. In addition, because of the complementarity between the HLS-CATCH method and the 10x Chromium library system, sequencing reagent costs to achieve 100x phased target coverage are more than 10-fold lower than that required to obtain 100x phased whole genome data.