Accelerate to discover

Back to filter

Related topics

IncuCyte Live-Cell Analysis System - nearly 3,000 publications and counting!

Sartorius

Jan 21, 2020

IncuCyte has now reached over 2,000 cited publications! Search our publications filter to see what exciting research is...

Development of superparamagnetic nanoparticles as an efficient contrast agent for multimodal imaging

Bruker Biospin

Jan 16, 2020

Gadolinium‐based contrast agents are used to provide diagnostic information in clinical magnetic resonance...

IncuCyte live-cell analysis system for live-cell visualization of neuronal activity

Sartorius

Jan 13, 2020

A major impediment to studying diseases affecting the human nervous system is the ability to monitor, analyze, and...

High molecular weight DNA from bone marrow aspirates samples in 4 hrs

BioNano Genomics

Dec 23, 2019

With Bionano Prep SP BMA DNA Isolation kit, transform the way you are isolating UHMW DNA from this complex sample type...

Jan 26, 2020

Cutting-edge analysis of Extracellular Microparticles using ImageStream Imaging Flow Cytometry

Amnis

Dec 16, 2019

Interest in extracellular vesicle biology has exploded in the past decade, since these microstructures seem endowed...

Bruker MRI consistent quantification

Bruker Biospin

Nov 29, 2019

Regardless of the method, stability and reproducibility are a must for many laboratories. Identical protocols must...

Targeted sequencing of highly homologous genes using Cas9 digestion

Sage Science

Nov 25, 2019

Integrated DNA extraction, digestion, and size-selection using HLS-CATCH were introduced for addressing the problem of...

Jan 26, 2020

Advancing Alzheimer's disease research with IncuCyte S3 for Neuroscience

Sartorius

Nov 12, 2019

IncuCyte S3 Live-Cell Analysis System for Neuroscience: enables real-time automated measurements of the dynamic changes...

Show all topics (10)

Tetraspanin Tspan9 regulates platelet collagen receptor diffusion and activation

Mar 2, 2017

Here we have characterized gene-trap mice lacking Tspan9. The mice were viable with normal platelet numbers and size. Tspan9-deficient platelets were specifically defective in aggregation and secretion induced by the platelet collagen receptor GPVI, despite normal surface GPVI expression levels. A GPVI activation defect was suggested by partially impaired GPVI-induced protein tyrosine phosphorylation. In mechanistic experiments, Tspan9 and GPVI co-immunoprecipitated and co-localised, but super-resolution imaging revealed no defects in collagen-induced GPVI clustering on Tspan9-deficient platelets. However, single particle tracking using total internal reflection fluorescence microscopy showed that GPVI lateral diffusion was reduced by approximately 50% in the absence of Tspan9. Therefore, Tspan9 plays a fine-tuning role in platelet activation by regulating GPVI membrane dynamics. 

Read more

Scientific paper

Related technologies: Cell interaction studies

Get more info

Riccardo Pasculli

Head of application support

Riccardo

Pasculli

+420 731 127 717

Send Message

Brand profile

Fluxion Biosciences

With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.

Related products

Core control system, integrated to any inverted microscope to introduce flow to your research

show detail

System that offers a fully-integrated solution for automated, high throughput shear flow assays

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey