Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma. BEZ235 is an effective dual PI3K/mTOR inhibitor, but it was withdrawn from early-phase clinical trials owing to poor solubility and on-target/off-tumor toxicity.

Sage Science distributes universal sequencing technology´s TELL-Seq linked-read NGS library prep kits used with very low sample inputs for de novo DNA sequencing, carried out easily in a PCR tube without the need for expensive instrumentation.

Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively. However, it cannot reveal a detailed depth-dependent distribution profile of transdermally delivered agents in the skin.

Repetitive behaviors are one of the behavioral hallmarks of neuropsychiatric disorders.
Resting state functional magnetic resonance imaging has been used to examine functional connectivity alterations in patients with these disorders.

This work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in LUSC, and suggests that NSD3-dependency renders LUSC therapeutically vulnerable to bromodomain inhibition.

Cytek Aurora is helping researchers around the world take their science further. See how in the 200+ publications in our resources center.

The incidence of respiratory disease is increasing throughout the world, and the demand for safe, effective drugs to tackle conditions such as asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and lung cancer is rising.