Accelerate to discover

The Role of Micro-CT in Imaging Breast Cancer Specimens

The goal of breast cancer surgery is to remove all of the cancer with a minimum of normal tissue, but absence of full 3-dimensional information on the specimen makes this difficult to achieve.

Jun 17, 2020

Scientific paper

Bruker´s micro-CT used for some of the World’s First in vivo COVID-19 Imaging Experiments

Bruker's BioSpin PreClinical Imaging Division reports the use of the Bruker SkyScan 1278 in vivo micro-CT system at the KU Leuven, Belgium, to support COVID-19-focused research.

Jun 9, 2020

Scientific paper

Accelerate your biomedical research

"Currently, we are using IncuCyte to determine inhibitory effect of various compounds on proliferation, to quantitatively determine cell migration and for cocultivations of fluorescently labelled cells (cytotoxicity assays).
We especially appreciate the quantitative nature of cell migration, proliferation in spheroids and fluorescence labelling capability – as well as capability to capture crucial processes in an ideal time point, especially in angiogenesis assays.
In future, we would like to move more to label-free kinetic monitoring, so that we would be able to test various types of cancer cells from patient samples."

Dr. Lucia Kučerová

Biomedical Research Center SAS, Bratislava, Slovakia

Insulin receptor substrate 1 is a substrate of the Pim protein kinases

The goal of these studies was to identify Pim substrate(s) that could help define the pathway regulated by these enzymes and potentially serve as a biomarker of Pim activity.

May 18, 2020

Scientific paper

A mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection

Soft tissue sarcomas pose a significant clinical challenge, with approximately 12,000 new diagnoses and an estimated 4,700 sarcoma-related deaths per year.

Jun 3, 2020

Scientific paper

Four-week individual caging of male ICR mice alters body composition without change in body mass

Could individual caging affect the physical composition of outbred mice? To investigate this, dual X-ray absorptiometry was used to compare the mass, bone mineral content and density between group and individual caged mice.

May 25, 2020

Scientific paper

Accelerate your biomedical research

"xCelligence system offers unique technology that can be easily employed to measure and quantify the efficacy of cell-based immunotherapies. Indeed, we have successfully implemented protocols that enable us to monitor the efficacy of CAR T mediated cytotoxicity toward adherent breast cancer cells. The greatest advantage of the system is the real-time instead of the end-point readout. The data collected using the RTCA system fill in a common gap concerning the kinetics of the cell-based cytotoxicity process."    

Magdalena Winiarska

WUM, Warszawa, Poland

Immunophenotyping Extracellular Vesicles using Amnis CellStream

Attempts to analyze EVs using traditional PMT- based flow cytometers has been hampered by the limit of detection of such small particles and their low refractive index.To overcome these limitations, we employed the Amnis CellStream flow cytometer.

May 29, 2020

Scientific paper

Detect structural variants at 1% allele fraction: Dive deeper into heterogeneous cancer samples

To get a complete picture of highly rearranged cancer genomes in heterogeneous samples, use Bionano genome imaging collecting up to 1600x coverage of a human genome and uncover large structural variations at variant allele fractions as low as 1%.

May 22, 2020

Scientific paper

Implementation of Micro CT in CAD/CAM dentistry for image processing and soft computing

Present radiology devices are playing an important role in clinical dentistry but their area of application is
limited due to harmful effects of x-ray exposure to human and high operating cost. 

May 4, 2020

Scientific paper

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