Accelerate to discover

Responsive fluorescence probe for detection of Hypochlorous acid in live cells and animals

In this work, a new fluorescence probe, PQI, was developed for monitoring of the HOCl level in biological samples. The fluorescence of PQI was found to be significantly increased, leading to “OFF‐ON” fluorescence response towards HOCl.

Jan 17, 2019

Scientific paper

Improved differentiation of Retinal Organoids stem cells derived using rotating-wall vessels

Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types self-patterning into a polarized, laminated architecture. In static cultures, organoid development may be hindered by limitations in diffusion of oxygen.

Jan 15, 2019

Scientific paper

Accelerate your biomedical research

"Currently, we are using IncuCyte to determine inhibitory effect of various compounds on proliferation, to quantitatively determine cell migration and for cocultivations of fluorescently labelled cells (cytotoxicity assays).
We especially appreciate the quantitative nature of cell migration, proliferation in spheroids and fluorescence labelling capability – as well as capability to capture crucial processes in an ideal time point, especially in angiogenesis assays.
In future, we would like to move more to label-free kinetic monitoring, so that we would be able to test various types of cancer cells from patient samples."

Dr. Lucia Kučerová

Biomedical Research Center SAS, Bratislava, Slovakia

Squaraine fluorophore as a NIR-fluorescent probe for the in vivo detection of diagnostic enzymes

An oligo(ethylene glycol)-functionalized squaraine fluorophore has been developed as an NIR-fluorescent probe that can detect and image the activities of a diagnostic enzyme (leucine aminopeptidase) both in vitro and in vivo. 

Nov 19, 2018

Scientific paper

CT‐analyzer plug‐ins: ROI shrink‐wrap and primitive ROI

The ROI shrink‐wrap gives the possibility to automatically generate a region‐of‐interest by adapting to the shape of selected objects and the primitive ROI create an image for the region of interest containing a certain edge as binary object.

Jan 7, 2019

Scientific paper

The need for ultra high field magnetic resonance imaging

MRI  is a noninvasive imaging technology that is known for its superior soft tissue contrast and ability to provide morphological or metabolic information. However, its inherently low sensitivity remains one of MRI’s major challenges.

Dec 17, 2018

Scientific paper

Accelerate your biomedical research

“IncuCyte is a powerful system to monitor the  effect of substances  on neurite growth and proliferation.”

Prof. András Dinnyés

BioTalentum, Gödöllő, Hungary

Cellular stress induces erythrocyte assembly and promotes microangiopathy

Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms leading to microvascular occlusion include von Willebrand factor (VWF), notably the formation of ultra-large von Willebrand factor fiber.

Dec 19, 2018

Scientific paper

Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies

Accurate labeling of endogenous proteins for advanced light microscopy in living cells remains challenging. Nanobodies have been widely used for antigen labeling, visualization of subcellular protein localization andinteractions. 

Dec 6, 2018

Scientific paper

The most advanced software for preclinical imaging research

Modern imaging laboratories hosting PET/MR instruments profit from the fully integrated common imaging platform spanning PET and MRI modalities. The simplicity and allows operators to put their focus on their research

Nov 7, 2018

Scientific paper

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