In conventional monolayer cell culture systems, cell nuclei show dynamic and cyclic changes in theirshape and height. This phenomenon is pronounced during metaphase (M-phase).Generally, confocal optical microscopes have superb capability for it.

The journal Nano Letters has recently published the article “Quantifying Local Molecular Tension Using Intercalated DNA Fluorescence”,in which authors used the correlative optical tweezers-fluorescence microscopy technology by Lumicks.

The company has just introduced the xCELLigence RTCA S16, which is the ideal entry level model for exploratory studies in cell biology. The S16 model uses a proprietary non invasive biosensor technology to quantify cell proliferation, morphology.

A variety of technologies for cell and tissue culture have been developed since the first use of glass or plastic substrates. Some of these culture techniques have been adapted with varying degrees of success to 3-D culture.

The new X-RAD 160 qube is suitable for either mounting on the lab bench or mobile on an optional wheeled cart, allowing irradiation procedures to be performed in the sterile environment of the lab.

Use whole-well, label-free imaging to automatically scan for clones and verify monoclonality. Integrated image processing identifies wells containing emerging colonies, allowing for the rapid identification of clones of interest.

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