Accelerate to discover

Back to filter

Related topics

Hypoxia in the Tumor Immune Microenvironment (TIME)

Bruker Biospin

Jun 6, 2024

Thursday, 11 July 2024, 16:00 CET | 10:00 EST
Zaver M. Bhujwalla, PhD...

X-RAD 320 for irradiation therapy during quantifying study for in vivo collagen reorganization

Precision X-Ray

Jun 5, 2024

Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation...

Use of MRI and microCT to evaluate gene therapy for the treatment of discogenic back pain

Bruker Biospin

Jun 4, 2024

MRI images were obtained using the 9.4T Bruker BioSpec system, equipped with 40 mm 1H quadrature volume resonator, and...

Exosome-Mediated Delivery of Small Molecules, RNA & DNA for Development of Novel Cancer Therapeutics

Spectral Instruments Imaging

Jun 3, 2024

Disha Moholkar of University of Louisville's Gupta Lab
Tuesday, June 11, 2024, 6:30 PM
...

Jun 18, 2024

Emulate in vivo conditions – introduce shear flow to your experiments with BioFlux system

Cell Microsystems

May 27, 2024

Most research is still conducted in vitro without the presence of flow. We use the BioFlux System to give you the...

High-frequency Ultrasound System For Preclinical Imaging

S-Sharp

May 13, 2024

The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...

“Range+T “ for Tight Sizing of HMW Libraries

Sage Science

May 10, 2024

We decided to do a deep dive into Range+T to get a better handle the method, and to develop best practices for using...

Jun 18, 2024

April 2024 publication revealing benefits of using intravital microscopy in trascriptomics studies

IVIM Technology

May 8, 2024

Transcriptional activation of Bmal1 drives the inflammatory activity of monocytes by modulating mitochondrial unfolded...

Show all topics (10)

Great ape genomes laid bare

Aug 3, 2018

Evan Eichler assembled a large team, including several Bionano scientists, to sequence and assemble two human, one chimpanzee, and one orangutan genome using high-coverage long-read sequencing and Bionano genome mapping. They also sequenced more than 500,000 full-length cDNA samples to construct de novo gene models and map transcript diversity in each ape lineage. Bionano mapping identified several larger, subcytogenetic structural differences that were not detected or sequence-resolved in previous genome assemblies. The authors identified 29 human-chimpanzee-orangutan inversions ranging from 100 kbp to 5 Mbp in size, of which 55% have not been previously described. More than 93% of inversions are flanked by large complex segmental-duplication blocks, 38% of which show evidence of other structural and copy-number variation at the boundaries of the inversion. Even long-read sequencing can’t typically span those long segmental duplications, which is why Bionano can detect such large inversions better than any other technology.

 

Scientific paper
Application

Get more info

Regina Fillerová

Field application specialist

Regina

Fillerová

+420 731 127 718

Send Message

Brand profile

BioNano Genomics

A revolutionary NanoChannel technology for Genome mapping of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias.

Related products

Genome maps of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias

show detail

Saphyr provides rapid, high-throughput, long-range genome mapping with unmatched structural variation discovery capabilities

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey