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Great ape genomes laid bare

Aug 3, 2018

Evan Eichler assembled a large team, including several Bionano scientists, to sequence and assemble two human, one chimpanzee, and one orangutan genome using high-coverage long-read sequencing and Bionano genome mapping. They also sequenced more than 500,000 full-length cDNA samples to construct de novo gene models and map transcript diversity in each ape lineage. Bionano mapping identified several larger, subcytogenetic structural differences that were not detected or sequence-resolved in previous genome assemblies. The authors identified 29 human-chimpanzee-orangutan inversions ranging from 100 kbp to 5 Mbp in size, of which 55% have not been previously described. More than 93% of inversions are flanked by large complex segmental-duplication blocks, 38% of which show evidence of other structural and copy-number variation at the boundaries of the inversion. Even long-read sequencing can’t typically span those long segmental duplications, which is why Bionano can detect such large inversions better than any other technology.

 

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BioNano Genomics

A revolutionary NanoChannel technology for Genome mapping of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias.

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