Accelerate to discover

Back to filter

Related topics

Small animal 13C-hyperpolarized MRI

Bruker Biospin

Feb 8, 2019

13C-Hyperpolarized molecules provide a unique signature for molecular processes relevant to a range of disease...

Oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts

Spectral Instruments Imaging

Jan 30, 2019

Pancreatic ductal adenocarcinoma has been increasing by 0.5% per year in the United States. This study describes the...

Responsive fluorescence probe for detection of Hypochlorous acid in live cells and animals

Spectral Instruments Imaging

Jan 17, 2019

In this work, a new fluorescence probe, PQI, was developed for monitoring of the HOCl level in biological samples. The...

IncuCyte webinar recording: CAR T-cell therapy, frontiers in cancer Immunotherapy

Sartorius

Jan 11, 2019

The success of immune checkpoint blockade adds new therapeutic category to Cancers are the most heterogenous group of...

Feb 20, 2019

CT‐analyzer plug‐ins: ROI shrink‐wrap and primitive ROI

Bruker Biospin

Jan 7, 2019

The ROI shrink‐wrap gives the possibility to automatically generate a region‐of‐interest by adapting to the shape of...

ACEA Biosciences launch xCELLigence RTCA software Pro for immunotherapy applications

Acea Biosciences

Dec 28, 2018

RTCA Software Pro is an integrated software package for running and analyzing real time cell analysis data from...

Cellular stress induces erythrocyte assembly and promotes microangiopathy

Fluxion Biosciences

Dec 19, 2018

Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...

Feb 20, 2019

The need for ultra high field magnetic resonance imaging

Bruker Biospin

Dec 17, 2018

MRI  is a noninvasive imaging technology that is known for its superior soft tissue contrast and ability to provide...

Show all topics (10)

Improved differentiation of Retinal Organoids stem cells derived using rotating-wall vessels

Jan 15, 2019

Herein, scientists report a bioprocess using Synthecon rotating-wall vessel (RWV) bioreactors to culture retinal organoids derived from mouse pluripotent stem cells. Organoids in RWV demonstrate enhanced proliferation, with well-defined morphology and improved differentiation of neurons including ganglion cells and S-cone photoreceptors. Furthermore, RWV organoids at day 25 (D25) reveal similar maturation and transcriptome profile as those at D32 in static culture, closely recapitulating spatiotemporal development of postnatal day 6 mouse retina in vivo. Interestingly, however, retinal organoids do not differentiate further under any in vitro condition tested here, suggesting additional requirements for functional maturation. Studies demonstrate that bioreactors can dramatically accelerate and improve organoid growth and differentiation for modeling retinal disease and evaluation of therapies.

Read the whole paper!

 

Scientific paper
Application
Video

Related technologies: 3D cell culture rotary system

Get more info

Riccardo Pasculli

Head of application support

Riccardo

Pasculli

+420 731 127 717

Send Message

Brand profile

Synthecon

Inovating 3D cell culture technology exploring the rotary culture system for tissue engineering, stem cell, tumor spheroid and more. Unique Rotary Cell Culture System (RCCS)  for 3D culturing both suspension and anchorage-dependent cells.

Related products

The disposable (single use) vessel culture systems are low cost, easy to use, rotary bioreactor systems that utilize disposable culture vessels to enable 3D cell culture.

show detail

The autoclavable RCCS use culture vessels designed for repeated autoclaving, and ideal for long-term use. Suitable for any of the Synthecon culture vessels supplied with variable speed motor drives equipped with tachometer.

show detail

The RCCS-SC systems are a unique 3D cell culture technology with scaled down size for economic and more efficient stem cells growth.

show detail

RCCMAX allows undisturbed 3D cultivation of cells in vitro condition with continuous supplementation of fresh media and oxygen.

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey