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Improved differentiation of Retinal Organoids stem cells derived using rotating-wall vessels

Jan 15, 2019

Herein, scientists report a bioprocess using Synthecon rotating-wall vessel (RWV) bioreactors to culture retinal organoids derived from mouse pluripotent stem cells. Organoids in RWV demonstrate enhanced proliferation, with well-defined morphology and improved differentiation of neurons including ganglion cells and S-cone photoreceptors. Furthermore, RWV organoids at day 25 (D25) reveal similar maturation and transcriptome profile as those at D32 in static culture, closely recapitulating spatiotemporal development of postnatal day 6 mouse retina in vivo. Interestingly, however, retinal organoids do not differentiate further under any in vitro condition tested here, suggesting additional requirements for functional maturation. Studies demonstrate that bioreactors can dramatically accelerate and improve organoid growth and differentiation for modeling retinal disease and evaluation of therapies.

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Synthecon

Inovating 3D cell culture technology exploring the rotary culture system for tissue engineering, stem cell, tumor spheroid and more. Unique Rotary Cell Culture System (RCCS)  for 3D culturing both suspension and anchorage-dependent cells.

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The disposable (single use) vessel culture systems are low cost, easy to use, rotary bioreactor systems that utilize disposable culture vessels to enable 3D cell culture.

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The autoclavable RCCS use culture vessels designed for repeated autoclaving, and ideal for long-term use. Suitable for any of the Synthecon culture vessels supplied with variable speed motor drives equipped with tachometer.

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RCCMAX allows undisturbed 3D cultivation of cells in vitro condition with continuous supplementation of fresh media and oxygen.

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