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Extensive assessment of Cytokine production on the NovoCyte Penteon flow cytometer

Agilent technologies

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Falling in love with Magnetic resonance

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Magnetic Resonance (MR) is more than just analytical science, it is unique, it is a passion that won’t let you go

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New scientific article using Attana Biosensors

Jun 1, 2016

A novel method for facile fabrication of glycopolymer-based iron oxide nanoparticles (GIONs) is developed.                                   Via perfluorophenylazide photochemically induced C–H insertion, alkynyl groups were introduced onto the polymer which was precoated on the iron oxide nanoparticle surface. GIONs were then prepared by conjugating the azide-functionalized carbohydrate to the introduced alkynyl groups via click chemistry. Polyvinyl alcohol-coated and dextran-coated iron oxide NPs were chosen as scaffolds to attach two different carbohydrates, α-D-mannose and β-D-glucose, to fabricate multivalent GIONs, respectively. The multivalent GIONs demonstrated high binding affinities towards the corresponding lectins in both protein and cell chips. As a proof of concept, fluorescent GIONs (Gal-RhB-IONPs) were fabricated, which showed selective and efficient internalization by ASGP-R overexpressing HepG2 cells targeted.

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Related technologies: Label-free protein analysis

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Attana

Attana biosensors provides a reliable, fast and versatile label-free method to study molecular interactions.

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