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Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome
Aug 16, 2019
The BluePippin was used for High Pass DNA size selection prior to library construction. ONT Promethion was used for...
Fluxion Biosciences launches custom liquid biopsy NGS panel development
Aug 14, 2019
Fluxion a leading developer of precision solutions for life science research and diagnostics, announced that can...
Superior flow cytometry data with NEW Curiox Laminar Wash systems - centrifuge - less washing
Aug 12, 2019
The Laminar Wash technology provides an advantage to scientists in processing suspension cells for flow cytometry....
Next-generation cytogenetics is here
Aug 9, 2019
On ESHG 2019 conference several oral and poster presentations compared Bionano optical mapping to clinical cytogenetics...
Electroporation using Lumascope: A sustainable method for Adipogenous Mesenchymal Stem Cells
Aug 7, 2019
Human mesenchymal stem cells derived from adipose tissue (AD-hMSCs) represent a promising source for tissue engineering...
The best way to fragment DNA for genomic and paired end library construction
Aug 5, 2019
Digilab NextGen Shear DNA Shearing offers the simplest, most reproducible, and most controllable method available for...
Software Update: Bionano releases a new pipeline for low Aalelic fraction SVs
Jul 31, 2019
Bionano Solve v3.4 is a major update that introduces an entirely new pipeline to detect SVs at low allelic fraction and...
On-cartridge preparation and evaluation of 68Ga-, 89Zr- and 64Cu-precursors for cell radiolabelling
Jul 29, 2019
Method of on-cartridge formation of gallium-68, zirconium-89 and copper-64 complexes in small volumes suitable for cell...
Jun 1, 2016
A novel method for facile fabrication of glycopolymer-based iron oxide nanoparticles (GIONs) is developed. Via perfluorophenylazide photochemically induced C–H insertion, alkynyl groups were introduced onto the polymer which was precoated on the iron oxide nanoparticle surface. GIONs were then prepared by conjugating the azide-functionalized carbohydrate to the introduced alkynyl groups via click chemistry. Polyvinyl alcohol-coated and dextran-coated iron oxide NPs were chosen as scaffolds to attach two different carbohydrates, α-D-mannose and β-D-glucose, to fabricate multivalent GIONs, respectively. The multivalent GIONs demonstrated high binding affinities towards the corresponding lectins in both protein and cell chips. As a proof of concept, fluorescent GIONs (Gal-RhB-IONPs) were fabricated, which showed selective and efficient internalization by ASGP-R overexpressing HepG2 cells targeted.
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