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Registering FDG/PET mouse and AMYViD/PET-CT rat studies to brain VOI atlases
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Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation
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New protocol: Analyze small extracellular RNAs with PippinHT
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Genoox, Bionano collaborate to enhance the detection of pathogenic SVs
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Outstanding return on investment with the xxpress qPCR thermal cycler
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AVATAR Improves transfection efficiency with high viability
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Creating a bold new future in ultrasound and photoacoustics
May 4, 2018
Fujifilm VisualSonics has been chosen as one of the top 10 visualization solution providers in the field of developing...
Jun 1, 2016
A novel method for facile fabrication of glycopolymer-based iron oxide nanoparticles (GIONs) is developed. Via perfluorophenylazide photochemically induced C–H insertion, alkynyl groups were introduced onto the polymer which was precoated on the iron oxide nanoparticle surface. GIONs were then prepared by conjugating the azide-functionalized carbohydrate to the introduced alkynyl groups via click chemistry. Polyvinyl alcohol-coated and dextran-coated iron oxide NPs were chosen as scaffolds to attach two different carbohydrates, α-D-mannose and β-D-glucose, to fabricate multivalent GIONs, respectively. The multivalent GIONs demonstrated high binding affinities towards the corresponding lectins in both protein and cell chips. As a proof of concept, fluorescent GIONs (Gal-RhB-IONPs) were fabricated, which showed selective and efficient internalization by ASGP-R overexpressing HepG2 cells targeted.
Related technologies: Single-molecule Interactions
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