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Real-time study of platelet formation under sheer-flow with Lumascope
Jun 18, 2018
Platelet formation was observed with Lumascope microscope in a uniform-sheer-flow biorector. Videos of the formation...
Early fetal sex determination using micro-volume of maternal plasma
Jun 16, 2018
A qPCR-based assay, SneakPeek Early Gender Test (Gateway Genomics) has been developed to determine fetal sex as early...
3R Compliant drug development studies
Jun 8, 2018
In preclinical imaging, magnetic resonance imaging (MRI) can be an attractive alternative to researchers who have...
Kinase study of cytotoxicity voted paper of the year.
Jun 6, 2018
Society of Toxicology voted a xCELLigence based paper the Paper of the Year. The study of cytotoxicity was done using...
Heterodimeric compounds with dual-targeting active against both HIV and tuberculosis.
Jun 4, 2018
Search for dual action drugs against both HIV and Tuberculosis has lead to the creation of heterodimeric compounds with...
Mutual destruction of deep Lung tumor tissues by nanodrug‐conjugated and CQ1 imaging cytometer
Jun 1, 2018
Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a...
Method to quantify local force distribution within biomolecular systems
May 24, 2018
The journal Nano Letters has recently published the article “Quantifying Local Molecular Tension Using Intercalated DNA...
Registering FDG/PET mouse and AMYViD/PET-CT rat studies to brain VOI atlases
May 22, 2018
Preclinical NeuroPET is employed widely in studies of stroke, ischemia, addiction and eurodegenerative diseases. In...
Jun 1, 2016
A novel method for facile fabrication of glycopolymer-based iron oxide nanoparticles (GIONs) is developed. Via perfluorophenylazide photochemically induced C–H insertion, alkynyl groups were introduced onto the polymer which was precoated on the iron oxide nanoparticle surface. GIONs were then prepared by conjugating the azide-functionalized carbohydrate to the introduced alkynyl groups via click chemistry. Polyvinyl alcohol-coated and dextran-coated iron oxide NPs were chosen as scaffolds to attach two different carbohydrates, α-D-mannose and β-D-glucose, to fabricate multivalent GIONs, respectively. The multivalent GIONs demonstrated high binding affinities towards the corresponding lectins in both protein and cell chips. As a proof of concept, fluorescent GIONs (Gal-RhB-IONPs) were fabricated, which showed selective and efficient internalization by ASGP-R overexpressing HepG2 cells targeted.
Related technologies: Single-molecule Interactions
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