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Webinar recording: Isolating ultra-high molecular weight (UHMW) DNA for genome analysis

BioNano Genomics

May 12, 2020

Watch the webinar from Bionano Genomics and learn the tips and tricks for isolating high quality UHMW DNA - right from...

Isoflux webinar: Accurate liquid biopsy approach reveals mutations in lung cancer patients

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Liquid biopsies aim to identify clinically actionable information from cell-free DNA (cfDNA) and circulating tumor...

Panel design principles to investigate COVID-19 immune response with the Cytek Aurora

Cytek Biosciences

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Learn about the Cytek Aurora and panel design tools available to help you design high quality full spectrum cytometry...

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Image quality is only one aspect of functional imaging with PET and SPECT and the ability to reproducibly extract...

May 29, 2020

xCELLigence system: rapid and sensitive, ideal for infectious viral assays.

Acea Biosciences

Mar 30, 2020

As the public health threat from COVID-19 and future emergent viruses continue to persist, the rapid, sensitive, and...

IncuCyte webinar: Organoids, iPSCs, and advanced cell models.

Sartorius

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Researchers are now moving from reductionist, 2D monoculture assay models to more complex 3D cell models, such as...

Webinar recording: Metabolic MR Imaging of Obesity

Bruker Biospin

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The study of fat distribution is important to understand the pathophysiology of obesity related disorders, diabetes...

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Webinar recording: Ex vivo microangioCT, advances in microvascular imaging

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Next generation karyotyping: detecting cancer-associated structural variants using optical maps

Apr 19, 2017

James Broach, PhD, Penn State Hershey, Pennsylvania, United States.

Identification of structural variants (SVs) is critical to the prognosis of acute myeloid leukemia (AML) and other hematologic malignancies. SVs are not readily identified by next generation sequencing methods and are currently diagnosed by cytogenetics, an intrinsically low resolution tool. Dr. James Broach from Penn State Hershey will discuss a new method for determining large SVs as a clinical tool for evaluating AML and other cancer genomes using Bionano optical mapping. Dr. Broach has applied this technology for detection of SVs in a variety of cancer cell lines and directly from leukemia patient blood samples.  In all cases, they have identified all the SVs reported by classic cytogenetic analysis and, in addition, a large number of translocations, deletions and insertions not observed by cytogenetics.

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Related technologies: Genome mapping

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Regina Fillerová

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BioNano Genomics

A revolutionary NanoChannel technology for Genome mapping of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias.

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