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ACEA webinar series: Using xCELLigence RTCA to study biofilms formation

Acea Biosciences

Feb 14, 2018

xCELLigence instruments are revolutionizing pure and applied biofilm research. Beyond gains in efficiency, the...

NovoCyte live technical webinar: a flow cytometry method for detecting bacteria in water

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Regulatory testing for microbiological water quality is often conducted by growing microbes on agar medium in visible...

Studying bacterial biofilm formation and stress responses using the BioFlux microfluidic platform

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Dr. Webber is a group leader at the Quadrum Institute and a leading authority on antimicrobial resistance. Recently,...

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Live technical webinar: measuring Calcium Flux by flow cytometry

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Accurate measurements of intracellular Ca2+ concentrations allows for a more comprehensive understanding of Ca2+...

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity


Aug 21, 2017

The success of immune checkpoint blockade adds a new therapeutic category to the cancer therapy repertoire. Despite...

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The C-Trap is the world’s first instrument that combines optical tweezers, confocal microscopy or STED nanoscopy and an...

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Optimization of (CAR) T cell design guided by sensitive sssessment of B cell killing

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Adoptive cellular therapy using chimeric antigen receptor (CAR) T cells has produced significant responses in patients...

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Next generation karyotyping: detecting cancer-associated structural variants using optical maps

Apr 19, 2017

James Broach, PhD, Penn State Hershey, Pennsylvania, United States.

Identification of structural variants (SVs) is critical to the prognosis of acute myeloid leukemia (AML) and other hematologic malignancies. SVs are not readily identified by next generation sequencing methods and are currently diagnosed by cytogenetics, an intrinsically low resolution tool. Dr. James Broach from Penn State Hershey will discuss a new method for determining large SVs as a clinical tool for evaluating AML and other cancer genomes using Bionano optical mapping. Dr. Broach has applied this technology for detection of SVs in a variety of cancer cell lines and directly from leukemia patient blood samples.  In all cases, they have identified all the SVs reported by classic cytogenetic analysis and, in addition, a large number of translocations, deletions and insertions not observed by cytogenetics.

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BioNano Genomics

A revolutionary NanoChannel technology for Genome mapping of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias.

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