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Linked-read sequencing advances understanding of cancers

Jul 8, 2019

A new study from the University of Connecticut Medical School, Jackson Labs, and collaborators demonstrate the utility of using emulsion based linked-read sequencing for cancer research.From a methods standpoint, linked-read sequencing requires only 1 ng of DNA input and produces haplotype phasing information. With a 1 ng input requirement, there is ample recovery in the PippinHT – users simply quantify the sample with a Qubit fluorometric assay, and dilute the sample accordingly. On a side note, SageHLS platform has the capability to provide very large targeted genomic regions, a great application for linked-reads given the low input requirement.