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IncuCyte webinar: high throughput approach to developing T- Cell immunotherapies

Sartorius

Jun 17, 2019

Immunotherapy for cancers involves artificially prompting the immune system to treat cancer. Many cancer cells have...

Low-dose imaging in a new preclinical total-body PET/CT scanner

Bruker Biospin

Jun 12, 2019

Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing...

Fluxion Biosciences and National Cancer Institute cooperate to validate IsoFlux for sequencing

Fluxion Biosciences

Jun 12, 2019

Fluxion with IsoFlux has partnered with the Cleveland Clinic. They are aiming to improve sensitivity by timing the...

Join the AVANCE Track & Keep your MRI on Track

Bruker Biospin

Jun 4, 2019

Your research depends on the scientific advances that you make with your MRI instrument. Take your instrument and your...

Jun 18, 2019

A novel method for isolating high-quality UHMW DNA from animal and human tissues

BioNano Genomics

May 31, 2019

New isolation protocol for isolating high-quality UHMW DNA from 10 mg of freshly frozen or liquid-preserved animal and...

ParaVision 7 software

Bruker Biospin

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The preclinical MRI software ParaVision 7 delivers unsurpassed image quality and enhanced productivity for both routine...

HLS-CATCH: Cas-9 assisted gene purification

Sage Science

May 24, 2019

The CATCH process  provides researchers with the most direct access to genes for study. Target regions are defined with...

Jun 18, 2019

Introducing the first EV isolation column capable of running 100 mL samples.

IZON

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As the EV field continues to grow and advance, so has the need for scalability in EV isolation. Izon is addressing this...

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New insight into Cas9 off-target activity

Jun 7, 2019

In the paper “DNA stretching induces Cas9 off-target binding and cleavage”  the data showed that, while Cas9 binds on-target sites tightly and specifically on DNA that is loose and relaxed, stretching the DNA by increasing the tension induces reversible off-target binding at multiple sites. Researchers found that these off-target binding events are driven by mechanical distortion of the DNA – such as the formation of DNA bubbles – and are guide-RNA-sequence dependent. These results suggest that DNA destabilization during cellular processes, such as transcription or replication, can express off-targets to Cas9 activity.

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Optical tweezers, Confocal microscopy, STED nanoscopy, Acoustic force spectroscopy for single-molecule biophysics. 

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Live, simultaneous and correlative visualization and manipulation of molecular interactions with sub-picoNewton force resolution and sub-nm position resolution.

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The first dedicated optical tweezers instrument specifically developed for high-resolution single-molecule force spectroscopy research.

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Acoustic Force Spectroscopy is a single-molecule, lab-on-a-chip technology in which acoustic waves are used to exert forces on thousands of biomolecules.

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