Accelerate to discover

Back to filter

Related topics

Bruker announces acquisition of preclinical and molecular imaging research software provider PMOD

Bruker Biospin

Aug 19, 2019

The PMOD software is widely used for the analysis of positron emission tomography (PET) studies in neurology,...

Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome

Sage Science

Aug 16, 2019

The BluePippin was used for High Pass DNA size selection prior to library construction. ONT Promethion was used for...

Fluxion Biosciences launches custom liquid biopsy NGS panel development

Fluxion Biosciences

Aug 14, 2019

Fluxion a leading developer of precision solutions for life science research and diagnostics, announced that can...

Superior flow cytometry data with NEW Curiox Laminar Wash systems - centrifuge - less washing

Curiox

Aug 12, 2019

The Laminar Wash technology provides an advantage to scientists in processing suspension cells for flow cytometry....

Aug 20, 2019

Electroporation using Lumascope: A sustainable method for Adipogenous Mesenchymal Stem Cells

Etaluma

Aug 7, 2019

Human mesenchymal stem cells derived from adipose tissue (AD-hMSCs) represent a promising source for tissue engineering...

The best way to fragment DNA for genomic and paired end library construction

Digilab

Aug 5, 2019

Digilab NextGen Shear DNA Shearing offers the simplest, most reproducible, and most controllable method available for...

New Cytek Full Spectrum Viewer tool, a powerful guide for your fluorochrome choices

Cytek Biosciences

Aug 2, 2019

Want to see which fluorochromes have unique signatures and which are identical? Then the Cytek Full Spectrum Viewer...

Aug 20, 2019

Software Update: Bionano releases a new pipeline for low Aalelic fraction SVs

BioNano Genomics

Jul 31, 2019

Bionano Solve v3.4 is a major update that introduces an entirely new pipeline to detect SVs at low allelic fraction and...

Show all topics (10)

New insight into Cas9 off-target activity

Jun 7, 2019

In the paper “DNA stretching induces Cas9 off-target binding and cleavage”  the data showed that, while Cas9 binds on-target sites tightly and specifically on DNA that is loose and relaxed, stretching the DNA by increasing the tension induces reversible off-target binding at multiple sites. Researchers found that these off-target binding events are driven by mechanical distortion of the DNA – such as the formation of DNA bubbles – and are guide-RNA-sequence dependent. These results suggest that DNA destabilization during cellular processes, such as transcription or replication, can express off-targets to Cas9 activity.

Discover more!

Application
Product news

Related technologies: Single-molecule Interactions

Get more info

Regina Fillerová

Field application specialist

Regina

Fillerová

+420 731 127 718

Send Message

Brand profile

LUMICKS

Optical tweezers, Confocal microscopy, STED nanoscopy, Acoustic force spectroscopy for single-molecule biophysics. 

Related products

Live, simultaneous and correlative visualization and manipulation of molecular interactions with sub-picoNewton force resolution and sub-nm position resolution.

show detail

The first dedicated optical tweezers instrument specifically developed for high-resolution single-molecule force spectroscopy research.

show detail

Acoustic Force Spectroscopy is a single-molecule, lab-on-a-chip technology in which acoustic waves are used to exert forces on thousands of biomolecules.

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey