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From thousands of SVS to a handful of candidate genes

BioNano Genomics

Mar 1, 2018

Bionano’s Variant Annotation Pipeline (VAP) saves researchers valuable time (and frustration) by annotating structural...

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Follow biological processes in vivo at the cellular level

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Cellvizio Lab uses unique probe-based Confocal Laser Endomicroscopy technology. Watch this recorded webinar to learn...

A novel real time imaging platform to quantify Macrophage Phagocytosis


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Phagocytosis is a specific form of endocytosis by which cells engulf and internalize solid matter. Macrophages,...

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How to build the largest genome ever, in 3 easy steps

BioNano Genomics

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Here we report the sequencing and assembly of the 32-gigabase-pair axolotl genome using an approach that combined...

Timelapse imaging of Drosophila melanogaster larva's central nervous system


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High-throughput observation of molecular motor activity & dynamics


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With LUMICKS’ C-Trap, it is possible to observe myosin activity,the processive motion, the binding kinetics along...

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A novel real-time CTL assay to measure designer T-cell function against HIV Env(+) cells

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To increase the immunosurveillance in HIV infection, we used retroviral vectors expressing CD4-chimeric antigen...

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On the origin of replication by means of Bionano mapping

Jan 26, 2018

Life only exists because of the ability of cells to replicate, and death can come early when a cell’s replication spins out of control. Yet exactly where eukaryotic cells start when their large genomes need to be copied is still somewhat of a mystery. Studies looking into replication origins have largely focused on simple organisms with smaller genomes. Observing this process in large genomes like ours is difficult because eukaryotic cells have up to 50,000 replication start points per cell per cycle, and even the most commonly observed replication origin in the genome functions as such in just 10 percent of cells. To find answers to the question of where and when replication starts in individual cells, one needs a technology that can image and identify large single DNA molecules that are fluorescently labeled at high resolution and throughput… and of course we knew just what technology that could be!

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Regina Fillerová

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BioNano Genomics

A revolutionary NanoChannel technology for Genome mapping of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias.

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