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"In our lab, we use microCT Skyscan 1276 for visualization of vasculature and cancer in mice model. Xtreme II is powerful tool for molecular imaging. In our research group, Xtreme II is commonly used to assess the biodistribution of novel drug candidates in small animal model."

Adam Novobilský, PhD

Dept. Pharmacology and Immunotherapy, Veterinary Research Institute, Brno, Czech Republic

SkyScan 1276 - Bruker Biospin

High-resolution, fast in-vivo desktop micro-CT

The SkyScan 1276 allows reconstructing non-invasively any cross section(s) through the animal body with possibilities to convert reconstructed dataset into realistic 3D-image and calculate internal morphological parameters including specific bone structural parameters. The image field of view allows full body mouse and rat scanning. The variable magnification allows scanning bone and tissue samples with high spatial resolution down to 2.8 µm pixel size. Variable X-Ray energy combined with a range of filters ensures optimal image quality for diverse research applications from lung tissue to bone with metal implants.

Further, the SkyScan 1276 in vivo micro-CT administers low radiation dose to the animals allowing multiple scans in longitudinal preclinical studies without the risk of unwanted radiation - induced side effects. The system can perform scanning with continuous gantry rotation and in step-and-shoot mode with fastest scanning cycle 3.9 sec.

The SkyScan 1276 system is supplied with exchangeable animal cassettes that can be used in all Bruker in-vivo imaging instruments such as MRI, micro-PET, micro-SPECT, bio-luminescence, biofluorescence, etc. to collect multimodal information. It allows co-registration of functional and morphological information from the same animal.

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https://www.bruker.com/products/microtomography/in-vivo-micro/skyscan-1276/overview.html
Miroslav Vecheta

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